单心室心脏病患者的母胎环境和神经发育
Samantha A Holmes1, Krista Young1, Kelly R Wolfe1
1Division of Cardiology, Department of Pediatrics, University of Colorado School of Medicine, Denver, CO.
The Journal of pediatrics
|December 13, 2025
概括
母胎环境受损 (MFE) 与单心室心脏病 (SVHD) 的儿童认知和语言发育不佳有关. 对这些婴儿来说,对不良产前暴露的早期监测至关重要.
科学领域:
- 儿童心脏病学 儿童心脏病学
- 神经发育儿科 神经发育儿科
- 孕产妇和胎儿医学 孕产妇和胎儿医学
背景情况:
- 单心室心脏病 (SVHD) 对受影响的儿童构成复杂的挑战.
- 母胎环境 (MFE) 可能显著影响早期神经发育轨迹.
- 了解MFE的影响对于优化SVHD人群的护理至关重要.
研究的目的:
- 研究患有SVHD的婴儿中受损的MFE和神经发育结果之间的联系.
- 在MFE中确定影响儿童发育的特定产前风险因素.
- 评估临床和社会经济因素对这些关联的影响.
主要方法:
- 对160名在产前诊断的SVHD患者 (2011-2022) 的回顾性分析.
- 通过在子宫内暴露于糖尿病,先兆子,烟草或高血压而定义的受损的MFE.
- 在12-36个月之间使用贝利婴儿和幼儿发育尺度 (BSID-III/IV) 进行神经发育评估.
主要成果:
- 暴露于受损的MFE与SVHD患者的认知和语言得分较低有关.
- 在对临床共变量和社会经济因素 (儿童机会指数) 进行调整后,这些关联得到了减弱.
- 在运动分数,新生儿并发症或死亡率/移植率方面没有发现显著差异.
结论:
- 受到影响的MFE与SVHD儿童的认知和语言发育缺陷有关.
- 临床和社会经济因素在调解MFE对结果的影响方面发挥着作用.
- 建议对暴露于不良产前条件的SVHD婴儿进行早期鉴定和监测.
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