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母亲和父亲的冲动性和青少年的表观遗传年龄加速

Michael V Cataluna¹, Rachel A Brown¹, Kalsea J Koss¹

¹Human Development and Family Science, University of Georgia, Athens, GA.

The Journal of pediatrics

|December 13, 2025

概括

儿童早期母亲的冲动性与青少年加速表观遗传衰老有关. 这一发现强调了母亲的行为作为潜在的环境压力因素,影响着发育过程中的生物衰老.

科学领域:

发展心理学发展心理学
表观遗传学在表观遗传学中,表观遗传学是指表观遗传学.
公共卫生公共卫生

背景情况:

父母的行为显著影响孩子的发展.
表观遗传衰老,生物年龄的衡量标准,可以受到环境因素的影响.
了解早期生命暴露对长期健康结果至关重要.

研究的目的:

调查儿童时期累积的父母冲动性暴露与青春期加速表观遗传衰老之间的关联.
为了确定母亲和父亲的冲动性是否对青少年表观遗传年龄产生不同影响.

主要方法:

利用了来自未来家庭和儿童福祉研究的数据,这是一个大型的美国出生队列.
在幼儿时期 (1-5岁) 通过自我报告评估父母的冲动性.
在9岁和15岁的青少年中,使用PhenoAge,GrimAge和DunedinPACE表观遗传钟测量了加速表观遗传年龄.

主要成果:

儿童早期母亲的冲动性与9岁至15岁的加速表观遗传衰老显著相关.
父亲的冲动性与加速表观遗传衰老没有显著的关联.
特定的表观遗传钟 (GrimAge,DunedinPACE) 证实了母亲冲动性和加速衰老之间的联系.

结论:

母亲的冲动性可能充当环境压力因素,导致青春期的表观遗传衰老加速.
父母的行为,特别是母亲的冲动性,应该在影响儿童发展的更广泛的社会和生态背景下加以考虑.
这些发现表明,解决父母行为的干预措施可能会影响长期的生物衰老轨迹.

关键词:

青春期青春期青春期表观遗传年龄表观遗传年龄父母的冲动性,就是父母的冲动性.

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