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Updated: Jan 8, 2026

Mapping Dysfunctional Protein-Protein Interactions in Disease
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Mapping Dysfunctional Protein-Protein Interactions in Disease

Published on: October 24, 2025

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探索基于变性化的检测工作流变化如何影响全球蛋白质-蛋白质相互作用预测

Tavis J Reed1, Laura M Haubold2, Josiah E Hutton2

  • 1Lewis-Sigler Institute for Integrative Genomics, Princeton University, Carl Icahn Laboratory, Princeton, NJ, 08544; Department of Computer Science, Princeton University, 35 Olden Street, Princeton, NJ, 08540; Department of Molecular Biology, Princeton University, 119 Lewis Thomas Laboratory, Princeton, NJ, 08544.

Molecular & cellular proteomics : MCP
|December 13, 2025
PubMed
概括

基于变性化的测试,如TPCA和I-PISA,显示出不同的蛋白质与蛋白质相互作用 (PPI) 网络. 纳入不溶性分数和优化工作流程显著提高了PPI景观映射,并减少了采样需求.

关键词:
基于离子的蛋白质组合溶解性改变.蛋白质与蛋白质的相互作用互动网络互动网络.蛋白质组学 蛋白质组学热近距离同聚合 热近距离同聚合时间STOF 超级超级

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