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识别自闭症患者及其未受影响的兄弟姐妹的肠道微生物组成差异:与临床特征的相关性

Jung-Chi Chang^1,2, Yu-Chieh Chen^1,2, Hai-Ti Lin^1,2

¹Department of Psychiatry, National Taiwan University Hospital and College of Medicine, Taipei, Taiwan.

Translational psychiatry

|December 13, 2025

概括

这项研究在自闭症谱系障碍 (ASD) 患者及其未受影响的兄弟姐妹中发现了独特的肠道微生物组成,这表明基于微生物的干预措施有可能改善与ASD相关的症状.

科学领域:

微生物组研究微生物组研究
神经发育障碍神经发育障碍
肠-大脑轴肠-大脑轴

背景情况:

新兴研究将自闭症谱系障碍 (ASD) 与肠道微生物组联系起来.
不受影响的兄弟设计提供了关于自闭症标志物和保护因素的见解.
对于亚洲人口的数据有限.

研究的目的:

研究自闭症个体,未受影响的兄弟姐妹 (SIB) 和典型的发展对照 (TDC) 的肠道微生物组成差异.
探索微生物特征与ASD症状,情绪/行为问题和胃肠道问题之间的关联.

主要方法:

分析了来自239名自闭症患者,102名SIB和81名TDC (4至25岁) 的新鲜便样本.
16S rRNA amplicon 序列 (Illumina V3V4) 的测序方法.
分类学多样性和差异丰度分析.

主要成果:

在SIB中更高的α多样性;与TDC相比,自闭症个体的β多样性发生变化.
在TDC中,蓝菌,Eubacterium hallii群,Anaerostipes等菌种的数量较高.
在SIB中,Prevotellaceae和Agathobacter占主导地位.

结论:

在ASD和SIB组中确定了独特的微生物组成.
肠道微生物群落与自闭症和胃肠道症状相关.
像Anaerostipes这样的特定微生物可能与减少社会障碍和内化问题有关,这表明微生物干预的潜力.

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