抗脂综合征表现为大动脉血栓症和中央静脉导管相关的血栓症:一个病例报告
Yujiao Chen1, Dongjing Li2, Yinghong Su3
1Department of Anesthesiology, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, China.
Thrombosis journal
|December 13, 2025
概括
抗脂综合征 (APS) 可以导致迅速的术后血栓形成,即使使用标准抗凝药. 早期诊断和量身定制的抗血栓策略对于管理这种原血栓性自身免疫性疾病至关重要.
科学领域:
- 心血管外科心血管外科
- 自身免疫性疾病 自身免疫性疾病
- 血栓形成的管理
背景情况:
- 抗脂综合征 (APS) 是一种原血栓性自身免疫性疾病.
- 外科手术期间的因素,特别是心肺绕道,可以使APS患者的高凝血能力恶化.
- 在心血管手术期间管理APS的证据有限.
研究的目的:
- 在患有抗脂综合征 (APS) 的患者中呈现快速,术后血栓形成的病例.
- 以突出诊断和管理挑战的APS在外科设置.
- 讨论多式疗法在稳定患有广泛血栓形成症的患者的有效性.
主要方法:
- 在心肺绕道下,为上升大动脉血栓进行手术性血栓切除.
- 术后监测和处理与导管相关的血栓形成 (CRT).
- 多模式治疗包括抗凝剂,抗血小板剂,皮质类固醇和修复药.
主要成果:
- 一名以前未被诊断的APS患者在心脏手术后发生了广泛的动脉和导管相关血栓形成.
- 标准的凝血查在手术前没有发现.
- 积极的多式疗法导致了临床稳定和预防进一步的血栓事件.
结论:
- 及时诊断APS和管理术后高凝血是具有挑战性的.
- 临床医生必须怀疑快速术后血栓形成的APS,即使有正常的凝血测试.
- 对于导管相关的血栓形成和针对APS量身定制的抗血栓策略的迅速干预至关重要.
相关概念视频
Venous Thrombosis I: Introduction
294
Venous thrombosis, the most common disorder of the veins, involves the formation of a thrombus or blood clot associated with vein inflammation. It can be classified as either superficial vein thrombosis or deep vein thrombosis.Superficial Vein Thrombosis: This involves the formation of a thrombus in a superficial vein, usually the greater or lesser saphenous vein. Though less severe than deep vein thrombosis (DVT), SVT can lead to complications if untreated.Deep Vein Thrombosis (DVT): This...
294
Venous Thrombosis III: Interprofessional Care
262
Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...
262
Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies
270
The key difference between Superficial Vein Thrombosis (SVT) and Deep Vein Thrombosis (DVT) lies in their location and severity.Clinical ManifestationsSVT typically presents with localized pain, tenderness, and redness along the course of a superficial vein, often accompanied by a palpable, cord-like structure under the skin. This condition is usually less dangerous than DVT but can be uncomfortable and may lead to complications such as cellulitis or, rarely, a clot extension into the deep...
270
Peripheral Artery Disease I: Introduction
288
Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...
288
Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation
318
Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
318
Venous Thrombosis IV: Nursing Management
182
Nursing management begins with a thorough assessment of the patient's health history. Key factors include trauma to veins, peripherally inserted central catheters, varicose veins, recent pregnancy or childbirth, surgery, bacteremia, prolonged bed rest, atrial fibrillation, COPD, heart failure, cancer, coagulation disorders, myocardial infarction, spinal cord injury, stroke, prolonged travel, recent bone fractures, and dehydration. Review medication intake, particularly oral contraceptives,...
182


