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Monitoring eIF4F Assembly by Measuring eIF4E-eIF4G Interaction in Live Cells
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通过降低eIF5A活性来抑制翻译延长会诱导启动的反抑制,限制瘤细胞增殖

Aristeidis P Sfakianos1, Rebecca M Raven2, Tom Smith2

  • 1MRC Toxicology Unit, University of Cambridge, Cambridge, UK. arissfak92@gmail.com.

Nature communications
|December 13, 2025
PubMed
概括

使用GC7准5A真核启动因子 (eIF5A),通过减少蛋白质合成来抑制癌细胞生长. 这种抑制会触发压力反应,影响线粒体功能,最终减少癌症的扩散.

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