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环保纳米级识别:基于MIP的电化学传感器,用于在制药和血清样本中选择性地确定阿巴卡维尔

Seyda Nur Samanci^1,2,3, S Irem Kaya⁴, Mehmet Altay Unal⁵

¹Department of Analytical Chemistry, Faculty of Pharmacy, Ankara University, Ankara, Türkiye.

Analytical and bioanalytical chemistry

|December 13, 2025

概括

使用分子印记聚合物 (MIP) 和多壁碳纳米管 (MWCNTs) 的新型电化学传感器提供了对阿巴卡维尔 (ABC) 的敏感和选择性检测. 这种MIP传感器提供了一种可靠的,低成本的工具,用于在各种样本中分析阿巴卡维尔.

科学领域:

电化学电化学电化学
材料科学材料科学材料科学
分析化学分析化学

背景情况:

阿巴卡维尔 (ABC) 是一种关键的抗病毒药物,需要敏感和选择性的检测方法.
分子印记聚合物 (MIP) 提供了定制的分子识别能力.
纳米材料可以提高电化学传感器的性能.

研究的目的:

设计和制造一个有利的电化学传感器用于阿巴卡维尔分析.
将MIP战略与纳米材料增强相结合,以提高灵敏度和选择性.
在现实世界样本中验证传感器的性能,并评估其绿色配置.

主要方法:

在玻璃碳电极 (GCE) 上通过光聚合制造使用烯胺 (ACR) 和阿巴卡维尔 (ABC) 制造MIP.
将氨基功能化的多壁碳纳米管 (MWCNT-NH2) 纳入MIP矩阵.
使用循环电压计 (CV),电化学阻抗光谱 (EIS),SEM和FTIR进行表征;优化传感器参数.

主要成果:

开发的ACR-ABC/MWCNT-NH2@MIP/GCE传感器显示了从0.2到1 pM的线性响应,并具有出色的相关系数 (0.999).
在标准溶液中达到26.5 fM,在血清样本中达到8.04 fM的非常低的检测极限 (LOD).
在血清和药片样本中显示出ABC对相关药物的高选择性,良好的重复性 (RSD% < 1.5%) 和可靠的恢复率 (98.99-102.01%).

结论:

集成的MIP和MWCNT电化学传感器为阿巴卡维尔的确定提供了一个高度敏感和选择性的平台.
传感器在复杂的矩阵 (如血清和制药配方) 中表现出色的性能.
该研究强调了这种传感器作为可靠,低成本和高效的分析工具的潜力,具有有利的绿色特征.

关键词:

阿巴卡维尔 (abacavir) 是一种药物.电化学传感器是一种电化学传感器.有分子印记的聚合物.纳米材料是一种纳米材料.

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