喉携带耐美西林黄金葡萄球菌:对局部根除治疗有效性的队列研究
Kristoffer Koch1,2,3, Anne Kathrine Schultz Christensen4, Niels Henrik Bruun5
1Department of Clinical Microbiology, Aalborg University Hospital, Hus L, Hospitalsbyen 1, 2. etage, 9260, Gistrup, Denmark. k.koch@rn.dk.
对抗甲素耐药黄金葡萄球菌 (MRSA) 喉携带者的局部治疗显示出中等成功. 没有额外危险因素的患者的根除率更高,这表明局部治疗对许多人来说是一个可行的选择.
科学领域:
- 传染性疾病 传染性疾病
- 微生物学 微生物学
- 公共卫生 公共卫生
背景情况:
- 消灭抗甲素黄金葡萄球菌 (MRSA) 是减少传播的关键.
- 喉携带MRSA对治疗成功提出了挑战.
- 对MRSA喉载体的最佳治疗策略需要进一步调查.
研究的目的:
- 评估MRSA喉载体的局部根除治疗的有效性.
- 为了确定患者,环境和与菌株相关的治疗失败的风险因素.
主要方法:
- 在丹麦北部地区 (2017-2020年) 的MRSA喉携带者的基于人口的队列研究.
- 排除标准:年龄<2岁,职业牲畜暴露,全身抗菌剂.
- 在治疗后6个月被定义为无MRSA的成功根除;多变量分析风险因素.
主要成果:
- 在完成随访的258名患者中,整体根除成功率为43.4%.
- 没有额外危险因素的患者获得54.7%的成功率.
- 与年轻年龄,非CC398菌株和MRSA阳性家庭成员相关的治疗失败.
结论:
- 局部治疗对于没有特定风险因素的MRSA喉携带者来说是一种潜在的有效策略.
- 超过一半的符合条件的患者通过局部治疗实现了长期根除.
- 局部治疗为全身抗生素提供了替代方案,考虑到其潜在的不良影响.
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