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Updated: Jan 8, 2026

Experimental Melanoma Immunotherapy Model Using Tumor Vaccination with a Hematopoietic Cytokine
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向LRBA触发CTLA4降解和抗瘤免疫力,用于癌症免疫疗法

Xiaolu Ge1, Liang Yu2, Lei Zhang1

  • 1Laboratory of Molecular Pharmacology and Drug Discovery, Institute of Chinese Materia Medica, The Fourth Clinical Medical College, Guangzhou University of Chinese Medicine; Shanghai Key Laboratory of Pancreatic Disease, Department of Gastroenterology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 201620, China.

Nature communications
|December 13, 2025
PubMed
概括

对脂聚糖体敏感的色类似蛋白 (LRBA) 缺乏影响抗瘤免疫力. 研究人员开发了针对LRBA的小分子LC427,以增强T细胞存活率并有效地对抗癌症.

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