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在预测糖尿病风险方面,体力表现超过握力:来自前性队列研究的证据

Mingyu Zhu¹, Qin Zhu¹, Hongxia Liu¹

¹Department of Geriatrics, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China.

Journal of translational medicine

|December 13, 2025

概括

通过5次椅子站测试来评估身体表现,预测新发糖尿病风险,特别是在年轻,瘦身的成年人中. 握力没有显著的预测价值. 这为早期糖尿病风险识别提供了一个实用的工具.

科学领域:

老年学是指老年学的学科.
代谢疾病代谢疾病
肌肉骨健康肌肉骨健康

背景情况:

糖尿病是一种重大的全球健康挑战.
传统的风险评估可能无法完全捕捉诸如胰岛素抵抗等潜在机制.
骨肌肉在葡萄糖处理中的作用表明,功能性评估可以提高风险预测.

研究的目的:

调查肌肉功能指标的预测价值,特别是握力和5次椅子站测试 (5-CST),用于新发糖尿病.
为了比较体力表现与肌肉力量在识别糖尿病风险方面的有效性.

主要方法:

来自中国健康与退休长度研究 (CHARLS) (2011-2020) 的6604名参与者的前性队列研究.
基线评估包括握力和5-CST.
新发型糖尿病是通过医生诊断来确定的; 考克斯比例危险模型用于分析,根据年龄,性别和BMI进行子组分析.

主要成果:

低体力表现 (以5-CST表示) 与新发糖尿病风险增加有关 (调整HR 1.219).
这种关联在年轻的成年人 (40-49岁) 和BMI<25 kg/m2的人群中更为明显.
在完全调整后,握力和连续测量5-CST时间都没有显示出与糖尿病风险的显著独立关联.

结论:

身体表现,特别是由5-CST评估的下肢功能,是新发糖尿病的更强的预测因素,而不是握力.
5-CST作为一种实用,低资源的工具,用于识别高风险个体,特别是年轻的,非肥胖的成年人.
这种功能性评估可以补充早期糖尿病风险分层的传统方法.

关键词:

糖尿病是一种糖尿病.胰岛素耐药性胰岛素耐药性是一种肌肉的力量肌肉的力量身体的表现身体的表现风险因素风险因素风险因素

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