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在多种长期疾病研究中测量结果选择的复杂性:对基于运动的康复试验的分析
James R Manifield1,2, Rachael A Evans3,4, Susan M Smith5
1Respiratory Sciences, University of Leicester, Leicester, UK. jm937@leicester.ac.uk.
Trials
|December 13, 2025
概括
对多种长期疾病 (MLTC) 的运动康复部分与核心结果集保持一致. 未来的试验需要纳入全面患者评估的所有基本领域.
科学领域:
- 康复医学 康复医学 康复医学
- 临床试验方法论 临床试验方法论
- 医疗保健服务研究 医疗服务研究
背景情况:
- 基于运动的康复为单一的长期疾病 (LTC) 提供了经过验证的好处.
- 对于多重LTC (MLTC) 患者的运动干预措施的有效性和最佳结果测量的证据仍然有限.
- 标准化结果措施对于开发和评估MLTC干预措施至关重要.
研究的目的:
- 将MLTC患者的运动康复试验的结果测量与多病症核心结果集 (COSmm) 进行映射.
- 将MLTC试验中的结果报告与单个LTC试验中的结果报告进行比较.
- 确定对MLTC种群的结果测量的差距.
主要方法:
- 对基于运动的MLTC康复进行两次系统审查的二次分析.
- 将结果措施分类和映射到COSmm领域.
- 从单个LTC干预的系统审查概述中提取结果数据.
主要成果:
- 分析了来自59个MLTC试验的217个结局措施.
- 运动能力和与健康有关的生活质量是最常见的结果领域.
- 虽然身体功能,生活质量,心理健康和坚持表现出与COSmm的一致性,但沟通和共享决策等领域没有得到解决.
- 单个LTC试验中的结果测量显示异质性,但与MLTC测量有相似之处.
结论:
- 目前针对MLTC的运动康复试验仅部分涵盖了COSmm中概述的领域.
- 显然需要将COSmm领域的全部范围纳入未来的MLTC干预试验,包括基于炼的康复.
- 这项研究强调了综合性结果评估在多病症研究中的重要性.
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