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治疗辐射诱导的异位形成症的介质干细胞治疗:系统性审查和网络元分析

Shen-Sui Li^1,2, Xu-Dong Tian^1,2, Ju-Kun Song^1,2

¹College of Stomatology, Guizhou Medical University, Guiyang, 550004, China.

Stem cell research & therapy

|December 13, 2025

概括

介质细胞干细胞 (MSC) 疗法在辐射诱导的静止症 (RIX) 中,在统计学上显著,但在临床上较小的唾液流量的改善. 目前的证据不支持MSC对标准护理的优越性,需要进一步的大规模试验.

科学领域:

再生医学是一种再生医学.
瘤科支持性护理
干细胞生物学干细胞生物学

背景情况:

辐射诱导的口 (RIX) 是头癌放射治疗的常见和严重的副作用.
临床前研究表明,介质干细胞 (MSC) 具有唾液腺保护和再生的潜力.
目前对RIX的MSC治疗的临床数据有限且碎片化.

研究的目的:

评估中干细胞 (MSC) 治疗中干细胞 (MSC) 治疗中干细胞 (RIX) 患者的安全性和有效性.
通过元分析合成现有的临床试验数据,以确定MSCs对唾液腺功能和患者报告结果的治疗影响.

主要方法:

在主要数据库 (PubMed,Wiley,Cochrane,CNKI) 进行了系统的文献搜索,截至2025年7月.
包含360名参与者的7项临床试验被纳入了元分析,重点关注非刺激的全唾液流量 (UWS) 作为主要终点.
二次结局包括刺激的全唾液流量 (SWS), Xerostomia问卷 (XQ) 评分和严重不良事件 (SAE),使用I2统计数据评估异质性.

主要成果:

分析显示,与对照组相比,在MSC治疗时,UWS的增加在统计上显著,但在临床上可以忽略不计 (0.02毫升/分钟) 与MSC治疗相比.
在MSC和对照组之间没有观察到SWS,XQ得分或严重不良事件 (SAE) 发生率的显著差异.
探索性分析表明,骨髓衍生的MSCs (BMMSCs) 和脂肪衍生的MSCs (ADMSCs) 之间存在潜在的差异,尽管由于有限的数据,这需要进一步调查.

结论:

MSC移植为RIX患者提供了统计学上显著但临床上边际的UWS改善,而不会增加严重的不良事件.
目前的证据并不能证明MSC治疗对RIX的传统治疗的优越性.
未来的大规模,精心设计的临床试验至关重要,以确定优化的MSC策略是否可以为RIX患者带来临床上有意义的益处.

关键词:

介质细胞干细胞介质细胞干细胞网络元分析网络元分析辐射诱导的异位静止症是辐射诱导的.系统性审查系统性审查

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