上腺素介导的兴奋波动驱动了反转的U形功能连接动态
Chuanjun Tong1, Weishuai Li2,3, Yijuan Zou4
1Institute of Neuroscience, International Center for Primate Brain Research, Center for Excellence in Brain Science and Intelligence Technology, State Key Laboratory of Genetic Evolution & Animal Models, Chinese Academy of Sciences, Shanghai, China. tongcj@ion.ac.cn.
大脑兴奋状态影响表现,遵循一个反转的U形. 这项研究揭示了这种模式的功能网络基础,由诺阿基因林驱动.
科学领域:
- 神经科学是一个神经科学.
- 系统神经科学 系统神经科学
- 认知神经科学 认知神经科学
背景情况:
- 兴奋状态动态地影响大脑功能和行为,这是由Yerkes-Dodson定律描述的概念.
- 这种反转的U形关系背后的特定功能网络机制尚未得到充分理解.
研究的目的:
- 调查激发调节的大脑活动和行为的功能网络基质.
- 阐明局部coeruleus-norepinephrine (LC-NE) 系统在塑造这些动态中的因果作用.
主要方法:
- 集成功能磁共振成像 (fMRI) 与人类和清醒的小鼠同时进行脑电图 (EEG).
- 利用了入侵性的多模式神经记录和小鼠中LC-NE神经元的有针对性的操纵.
- 在清醒的小鼠中,结合EEG-fMRI与LC-NE系统操纵.
主要成果:
- 发现兴奋水平以反转的U形方式调节全球功能连接 (FC) 动态,在中度兴奋时达到顶峰.
- 证明了这些反转的U形FC动态和兴奋调节的行为表现之间的显著相关性.
- 揭示了LC-NE系统对这些取决于兴奋的FC动态的因果贡献,反转的U形取决于基线兴奋.
结论:
- 揭示了依据耶克斯-多德森定律的功能网络基础.
- 确立了源自LC-NE系统的上腺素 (NE) 介导的兴奋波动在驱动观察到的反转U形大脑动态和行为方面的因果作用.
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