神经生理学证据 运动准备功能障碍 在内在语音和其与听觉口头幻觉的关联 在精神分裂症谱系障碍中的神经生理学证据
Lawrence Kin-Hei Chung1,2, Thomas J Whitford1,3, Oren Griffiths4
1School of Psychology, University of New South Wales (UNSW Sydney), Sydney, NSW 2052, Australia.
Schizophrenia bulletin
|December 14, 2025
概括
精神分裂症的听觉语言幻觉 (AVH) 可能源于运动准备缺陷. 这项研究在AVH患者中发现了独特的神经模式,表明自我监测机制受损.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 认知科学 认知科学
背景情况:
- 听觉语言幻觉 (AVH) 与冠状性放电功能障碍有关.
- 运动准备在内在语音预测中的作用尚未完全被理解.
研究的目的:
- 调查AVH与附带负变异 (CNV) 之间的关系,这是一种动作准备的电生理学标记.
- 测试假设,内在言语中运动准备障碍有助于AVH.
主要方法:
- 使用脑电图 (EEG) 来记录大脑活动.
- 参与者想象内在的言语 (主动状态) 或被动地倾听 (被动状态).
- 在健康的对照组 (HC),患有AVH的精神分裂症患者 (SZAVH+) 和没有AVH的精神分裂症患者 (SZAVH-) 中,比较了以内言语为先的晚期CNV.
主要成果:
- 与被动倾听相比,健康对照在内言想象过程中表现出更负面的晚期CNV.
- 精神分裂症患者 (无论是SZAVH+还是SZAVH-) 在两种条件下都显示出积极的潜力.
- 在SZAVH+的内在语言想象过程中,减少积极性的明显模式显著预测了AVH状态.
结论:
- 研究结果表明,在精神分裂症谱系障碍中,内在言语期间的运动准备功能障碍.
- 预动神经指数的异常可能是AVH的基础,因为它反映了不准确的预测编码.
- 这项研究为AVH中预测形成异常提供了新的视角.
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