保存的HSFA1依赖色素动力学驱动植物热应激反应
Ming-Jen Yen1, Kuan-Hung Lin1, Lavakau Thalimaraw2
1Institute of Plant and Microbial Biology, Academia Sinica, Taipei 115201, Taiwan.
Cell reports
|December 14, 2025
概括
像HSFA1这样的热冲击转录因子 (HSF) 通过控制热应激反应的染色质可访问性来调节基因表达. 这种机制在植物,小鼠和人类中得到保护,有助于应激适应.
科学领域:
- 植物生物学 植物生物学
- 分子生物学分子生物学
- 遗传学 是一个遗传学.
背景情况:
- 细胞在环境压力期间改变染色质以控制基因表达.
- 热应激 (HS) 导致植物中的染色质变化,但热冲击转录因子 (HSF) 在这个过程中的作用和保护是未知的.
研究的目的:
- 研究HSFs在热应激诱导的染色质重塑中的作用.
- 确定HSF介导的染色质调节的进化保存.
- 探索ABA,HSFA1和染色体重塑之间的相互作用.
主要方法:
- 使用了Marchantia polymorpha Mphsf和Arabidopsis thaliana Athsfa1s突变的植物.
- 进行了基因调节网络建模.
- 开发了一个机器学习框架,整合了染色体可访问性和 cis-regulatory element (CRE) 数据.
主要成果:
- 确定HSFA1是HS诱导的CRE可访问性的关键调节者,在陆地植物,小鼠和人类中保存.
- 发现了并行转录因子子网,MpWRKY10和MpABI5B作为间接负的HS监管器.
- 证明了ABA通过HSFA1调节基因表达,而不会改变染色质结构.
结论:
- HSFA1是热应激期间染色质可访问性的保守关键调节器.
- 转录因子协调染色体结构以适应应力.
- 机器学习可以预测跨物种的应激反应基因表达模式.
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