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头部和部放射治疗后的大脑血管事件:系统性审查和元分析
Kennedy Ayoo1, Elliot Koo2, Noémie Villemure-Poliquin3
1Department of Vascular Surgery, University of Toronto. Toronto, Ontario, Canada; Institute of Health Policy, Management and Evaluation (IHPME), University of Toronto. Toronto, Ontario, Canada.
Oral oncology
|December 14, 2025
概括
头部癌症的头部放射治疗 (RT) 增加了脑血管事件的风险,包括缺血性中风. 需要进一步的研究来用现代RT技术量化这种风险.
科学领域:
- 在瘤学瘤学.
- 神经学 神经学
- 放射学 放射学是一门学科.
背景情况:
- 头部癌症的头部辐射疗法 (RT) 与脑血管事件 (CVEs) 的风险增加有关.
- 以前的研究表明,RT与诸如动脉狭窄和中风等疾病之间存在潜在的联系.
- 本综述的重点是量化CVE的发病率和RT治疗患者中缺血性中风的相对率 (RR).
研究的目的:
- 系统地审查和报告HNC的RT后CVEs的发生率.
- 为了确定与非RT人群相比,在接受RT治疗的患者中缺血性中风的相对率 (RR).
- 综合目前关于与HNC治疗相关的大脑血管风险的证据.
主要方法:
- 进行了全面的文献搜索,以确定相关出版物.
- 关于CVE发病率和缺血性中风的RR的数据是从符合条件的研究中提取的.
- 进行了元分析,以计算CVE发病率和缺血性中风RR的综合估计.
主要成果:
- 在2598个获取的引用中,有50项研究符合纳入标准.
- 动脉狭窄的发病率差异很大 (0%-40%),随访时间从6个月到150个月不等.
- 在RT患者中,缺血性中风的RR升高 (HR 1.33与手术相比,HR 1.29与一般人群相比).
结论:
- 接受RT的头癌患者的缺血性中风风险明显增加.
- 在先进的技术技术时代,这种风险的确切程度需要进一步调查.
- 未来的研究应侧重于评估使用现代强度调节放射治疗的脑血管风险.
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