水的消耗有助于孕产妇的PFAS暴露:从来源到代谢干扰
Wei Chang1, Yong-Wei Xiong1, Jian Sun1
1Department of Toxicology, School of Public Health, and Center for Big Data and Population Health of IHM, School of Public Health, Anhui Medical University, Hefei 230032, China; Key Laboratory of Environmental Toxicology of Anhui Higher Education Institutes, Hefei 230032, China; Key Laboratory of Population Health Across Life Cycle (Anhui Medical University), Ministry of Education of the People's Republic of China, Hefei 230032, China.
Environment international
|December 14, 2025
概括
和多醇基物质 (PFAS) 污染水源,饮用水处理厂的清除能力有限. 孕产妇血清PFAS水平更好地由源水预测,影响脂质代谢并构成健康风险.
科学领域:
- 环境化学环境化学
- 毒理学 毒理学 毒理学
- 生物化学 生物化学
背景情况:
- 和多基基物质 (PFAS) 是持久性环境污染物,具有已知的人类健康风险.
- 了解PFAS从水中转移到人类及其代谢影响至关重要,但仍然不清楚.
研究的目的:
- 调查PFAS从各种水源转移效率 (TE) 进入母体血清.
- 通过脂管学和机器学习阐明将PFAS暴露与人类疾病相关的代谢途径.
主要方法:
- 在源水,自来水和饮用水处理厂 (DWTP) 水中对30种PFAS的综合分析,以及母体血清和297种脂质物种.
- 应用SHAP (沙普利添加剂解释) 框架来量化PFAS来源和血清脂质反应.
- 利用机器学习来识别PFAS诱导的母亲血清脂质代谢中的干扰.
主要成果:
- PFAS在源水中普遍存在,其中PFBA,PFPeA, 6:2 FTS,PFOA和PFOS占主导地位.
- 在DWTP中,PFAS的去除程度有限 (大多数测试化学品的去除率低于50%).
- 源水PFAS度比自来水更好地预测母亲血清PFAS.
- 特定的PFAS (HFPO-DA,N-MeFOSAA) 破坏了母体血清葡萄糖脂稳定性 (PC,LPC),表明代谢风险.
结论:
- 源水污染比自来水更直接地表明母亲暴露于PFAS的情况.
- 暴露于PFAS对母亲的脂质代谢,特别是糖脂的恒常性构成风险.
- 除了饮用水处理之外,还需要一个全面的战略来解决水的PFAS污染问题.
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