药物相关的骨缩:一个基于证据的2025年立场声明,来自韩国多学科工作组
Jin-Woo Kim1, Sung-Hye Kong2, Jae-Young Kim3
1Department of Oral and Maxillofacial Surgery, Ewha Womans University College of Medicine, Seoul, Korea.
Endocrinology and metabolism (Seoul, Korea)
|December 14, 2025
概括
与药物相关的下巴骨硬化 (MRONJ) 准则已为韩国更新. 建议包括药物特定假期和早期手术干预,以改善MRONJ管理中的患者结果.
科学领域:
- 口腔和牙面部外科手术
- 内分泌学 在内分泌学.
- 骨和矿物质研究研究
背景情况:
- 与药物相关的骨 (MRONJ) 是一个日益增长的全球挑战,由于人口老龄化和抗吸收剂的使用增加.
- 现有的临床指南需要根据特定的医疗保健环境进行定制,需要采用多学科的方法.
研究的目的:
- 制定基于证据的临床指导方针,用于针对韩国医疗保健环境的MRONJ预防,诊断和管理.
- 通过明确的决策框架,标准化MRONJ护理,减少临床混乱,改善患者的治疗结果.
主要方法:
- 一个涉及五个韩国学术协会的多学科工作组被召集.
- 通过全面的文献审查和对有争议的话题进行三轮专家意见调查,达成了共识.
- 为诊断标准,分期,预防和治疗药物假期以及治疗策略制定了指导方针.
主要成果:
- 诊断标准肯定了标准定义,允许基于临床/放射证据的诊断,即使8周的时间框架没有达到.
- 为了早期检测和预防,保持0阶段;推药物特定的预防性药物假期 (例如,口服双酸盐2个月).
- 在所有MRONJ阶段都提倡早期和积极的外科干预,并得到优越长期结果的证据支持.
结论:
- 本立场声明为MRONJ管理提供了一个独特的,基于证据的韩国临床实践指南.
- 主要建议侧重于优化药物假期和促进早期手术治疗,以减轻MRONJ风险和改善患者护理.
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