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A GPC3-targeting Bispecific Antibody, GPC3-S-Fab, with Potent Cytotoxicity
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双特异抗体的一般化最小PBPK-PD模型:在药物开发中的案例研究和应用

Phillip Spinosa1, Louis Joslyn1, Saroja Ramanujan1

  • 1Genentech Inc., South San Francisco, California, USA.

CPT: pharmacometrics & systems pharmacology
|December 14, 2025
PubMed
概括

一个新的最小生理学基础的药理动力学 (mPBPK) 模型预测双特异抗体 (bsAb) 药理动力学和目标参与. 该模型有助于优化bsAb设计,并预测新型疗法的临床性能.

关键词:
这是一种T细胞依赖双特异抗体.双特异抗体 PK 建模双特异抗体对大分子进行最小的PBPK建模.

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