在面包涂层过程中早期预测平板电脑缺陷
Joona Sorjonen1, Luis Martin de Juan2, Pirjo Tajarobi3
1School of Pharmacy, University of Eastern Finland, Kuopio, Finland.
概括
在制造过程中预测平板电脑的缺陷,例如在制造过程中发生破片是具有挑战性的. 这项研究使用破裂模型和离散元件方法 (DEM) 模拟来预测面板涂层和压缩机测试中的缺陷,通过仔细校准显示出有希望.
科学领域:
- 制药制造业 制药制造业 制药制造业
- 材料科学 材料科学 材料科学
- 计算机建模 计算建模
背景情况:
- 平板电脑的外观是一个关键的质量属性,直接影响患者的感知.
- 制造过程中的机械应力可能会导致视觉缺陷,如边缘破碎.
- 预测这些缺陷是具有挑战性的,特别是在技术转让和扩展期间.
研究的目的:
- 为了评估在机械应力下预测药片缺陷的数量和严重程度.
- 评估两个压力环境:面膜涂层和冷凝器测试.
- 使用校准的断裂模型与离散元件方法 (DEM) 模拟.
主要方法:
- 使用滴滴测试与两个安慰剂配方 (曼尼托:MCC和MCC:基酸) 校准了一个破裂模型.
- 使用离散元件方法 (DEM) 模拟来估计涂层板中的碰撞参数.
- 使用校准模型预测面膜涂层和压器测试场景中的缺陷.
主要成果:
- 该模型准确地预测了面板涂层中的缺陷严重程度 (I-III类),但低估了I类缺陷.
- 数字预测对模型参数校准非常敏感,特别是在轻微损坏方面.
- 压器预测过多的缺陷,表明在高碰撞环境中的局限性,并突出涂层中磨损的贡献.
结论:
- 开发的模型显示了指导平板电脑缺陷预测的潜力,特别是在精心校准的低事件条件下.
- 在面板涂层 (磨损) 和冷凝器 (频繁碰撞) 测试之间观察到损伤机制的差异.
- 需要进一步改进,以提高轻微缺陷和高碰撞场景的预测准确度.
相关概念视频
01:28Factors Influencing Drug Absorption: Pharmaceutical Parameters
377
Solid dosage forms such as tablets and capsules undergo rigorous manufacturing processes to ensure stability and effectiveness. Their dissolution and absorption properties are influenced significantly by the choice of excipients (inactive ingredients that serve various roles in the formulation), and the methodology applied during production. The manufacturing parameters, such as compression force and granulation techniques, significantly affect dissolution rates. Elevated compression forces...
377
01:18Formulation and Manufacturing Process: Physical Attributes of Generic Tablets and Capsules
280
Bioequivalence in generic drugs, such as tablets and capsules, refers to their pharmaceutical equivalence to the brand-name counterparts. However, for therapeutic equivalence, manufacturers must also consider physical attributes like size, shape, and weight (FDA Guidance for Industry, December 2003). Discrepancies in these aspects could impact patient compliance and cause medication errors. For instance, swallowing difficulties, often experienced with larger tablets or capsules, can lead to...
280