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来自有血友病A和没有血友病A的个体的T细胞对因子VIII的相同表位反应

Pooja Vir1, Ahmad Faisal Karim1, Devi Gunasekera1

  • 1Uniformed Services University of the Health Sciences, Bethesda, MD, USA; The Henry M, Jackson Foundation for the Advancement of Military Research, Inc., Bethesda, MD, USA.

Journal of thrombosis and haemostasis : JTH
|December 14, 2025
PubMed
概括

健康的个体拥有CD4+ T细胞,可以识别与血友病A患者相同的因子VIII (FVIII) 表位. 这一发现使得FVIII中T细胞表皮图的绘制能够使用来自健康捐献者的较小血液样本.

关键词:
血友病A型 血友病A型 血友病第八个因子的因素.免疫耐受性 免疫耐受性T细胞表位.T细胞表位. 蛋白质的设计 蛋白质的设计

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