确定血清蛋白转化酶9型素/素 (PCSK9) 的参考间隔
Rosaria Vincenza Giglio1, Luisa Agnello1, Anna Maria Ciaccio2
1Department of Biomedicine, Neurosciences and Advanced Diagnostics, Institute of Clinical Biochemistry, Clinical Molecular Medicine, and Clinical Laboratory Medicine, University of Palermo, Palermo, Italy; Department of Laboratory Medicine, University Hospital "Paolo Giaccone", Palermo, Italy.
Clinica chimica acta; international journal of clinical chemistry
|December 14, 2025
概括
这项研究确定了在健康成年人中血清蛋白转化酶细素/素9型 (PCSK9) 的第一个参考间隔. 根据性别和年龄,PCSK9水平有所不同,这凸显了心血管疾病研究中个性化解释的必要性.
科学领域:
- 心血管疾病研究研究
- 脂质代谢研究 研究脂质代谢研究
- 生物标志物发现发现
背景情况:
- 蛋白转化酶亚提利辛/凯类型9 (PCSK9) 对于脂质代谢和心血管疾病治疗点至关重要.
- 缺乏循环PCSK9的确定的参考间隔 (RIs),阻碍了临床和研究应用.
- 这项研究旨在在健康成年人群中确定血清PCSK9 RI.
研究的目的:
- 在健康的成年人群中建立血清PCSK9参考间隔 (RIs).
- 调查人口和生物变量对PCSK9水平的影响.
- 为PCSK9测量的临床解释提供基础.
主要方法:
- 招募了132名健康成年人 (年龄在18-65岁),他们的脂质样本正常,没有相关的病史.
- 使用经过验证的ELISA测定方法测量血清PCSK9度.
- 应用统计分析,包括符合CLSI指南的RI计算和性别/年龄分层.
主要成果:
- 血清PCSK9水平的平均值为428±119 ng/mL.
- 在女性中,PCSK9度明显高于男性.
- 在PCSK9水平和年龄 (r=0.36,p<0.001) 之间观察到温和的正相关性.
- 总体RI在201至659ng/mL之间;分层RI显示出与性别和年龄相关的显著差异.
结论:
- 这项研究提供了第一个严格推导的血清PCSK9在健康的高加索人群中的参考间隔.
- 根据性别和年龄观察到的PCSK9水平的变化强调了个性化参考值的必要性.
- 这些发现支持PCSK9测量在心血管风险评估中的临床实用性.
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