由STING驱动的TFEB/TFE3激活建立了一个负反循环,以控制免疫平衡
Yuyuan Wang1, Yu Luo1, Fei Zhou1
1Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou 310014, China.
Cellular signalling
|December 14, 2025
概括
转录因子EB (TFEB) 和TFE3调节溶解体和cGAS-STING通路. 这种交叉连接在先天免疫中产生负反循环,增强细胞存活率并维持免疫恒常性.
科学领域:
- 细胞生物学 细胞生物学
- 免疫学 免疫学 免疫学
- 分子生物学分子生物学
背景情况:
- 溶解体在细胞平衡和免疫反应中起着至关重要的作用.
- 循环GMP-AMP合成酶 (cGAS) 刺激干扰素基因 (STING) 途径是天生的免疫系统的关键组成部分.
- 这些通路的失调会导致各种免疫系统疾病.
研究的目的:
- 总结一下最近关于转录因子EB (TFEB) 和转录因子E3 (TFE3) 在先天免疫中的作用的发现.
- 为了阐明 lysosomal 功能和cGAS-STING 途径之间的交叉声.
- 讨论这种相互作用对免疫平衡和细胞存活的影响.
主要方法:
- 最近研究的文献综述.
- 分析将TFEB/TFE3, lysosomes和cGAS-STING通路连接在一起的分子机制.
- 关于IRF3酸化,IFN分泌和caspase-3激活的实验证据的讨论.
主要成果:
- TFEB和TFE3作为关键的调节剂,桥接着溶酶体和cGAS-STING通路.
- 一个TFEB/TFE3介导的负反循环抑制了过度的先天免疫反应.
- 这种途径抑制IRF3酸化,减少IFN分泌,抑制caspase-3激活,从而提高细胞存活率.
结论:
- 通过防止过度活跃的免疫反应,TFEB和TFE3对于维持免疫平衡至关重要.
- 溶解体与cGAS-STING通路之间的相互作用,由TFEB/TFE3调节,是先天免疫的一个新型自我调节机制.
- 了解这种交叉通话为与免疫相关的疾病提供了新的治疗点.
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