在减少硫酸盐和硫酸盐的细菌中的D-cysteinolate降解途径
Xumei Liu1, Yiling Hu1, Junwei An2
1New Cornerstone Science Laboratory, School of Pharmaceutical Science and Technology, Tianjin University, Tianjin, China; Frontiers Science Center for Synthetic Biology (Ministry of Education), Tianjin University, Tianjin, China; Key Laboratory of Systems Bioengineering (Ministry of Education), School of Chemical Engineering and Technology, Tianjin University, Tianjin, China.
The Journal of biological chemistry
|December 14, 2025
概括
研究人员发现了肠道细菌中D-cysteinolate降解的新途径. 这一发现对于了解人类肠道微生物群中的硫代谢和来自海洋食物的硫化 (H2S) 生产至关重要.
科学领域:
- 微生物学 微生物学
- 环境科学 环境科学
- 生物化学 生物化学
背景情况:
- 硫酸盐是普遍存在的环境化合物,对硫代谢至关重要.
- 减少硫酸盐和硫酸盐的细菌在无氧环境中产生硫化 (H2S).
- D-cysteinolate 在海洋生态系统中丰富,但其无氧降解是未知的.
研究的目的:
- 识别和描述无氧D-氨酸酸降解途径.
- 研究这种途径在环境和肠道细菌中的作用.
- 阐明涉及D-cysteinolate分解的生物化学步骤.
主要方法:
- 基因组分析以确定基因集群.
- 生物化学测试以表征酶活动.
- 从环境和肠道样本中培养硫酸盐和硫酸盐减少细菌.
主要成果:
- 在细菌中发现了一种用于D-cysteinolate降解的新型基因集群.
- 该途径涉及D-cysteinolate到L-cysteate的表皮化和氧化.
- 进一步降解产生氨,酸盐和硫酸盐,最终导致H2S的产生.
结论:
- 这项研究揭示了D-cysteinolate的完整无氧降解途径.
- 这条通路存在于海洋环境和人类肠道中的细菌中.
- 这些发现为了解肠道微生物群中来自海洋食物的H2S生产提供了基础.
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