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施罗丁格的猫悖论:MAMMI PET与Ga-FAPI能否确定乳腺癌中对新辅助化疗的病理完整反应?

Melis Oflas¹, Duygu Has Simsek¹, Ravza Yilmaz²

¹Department of Nuclear Medicine, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.

Cancer biotherapy & radiopharmaceuticals

|December 14, 2025

概括

这项研究表明,使用MAMMI PET的定量68Ga-FAPI PET/CT可改善经过新辅助化疗 (NACT) 后乳腺癌患者的病理完整反应评估. 虽然对乳房有效,但其对股疾病检测的敏感性需要进一步研究.

科学领域:

在瘤学瘤学.
核医学是一种核医学.
放射学放射学是一门学科.

背景情况:

新辅助化疗 (NACT) 是乳腺癌的标准治疗方法,需要对治疗反应进行准确的评估.
病理完整反应 (pCR) 是一个有利预后的关键指标.
目前的成像方法在NACT后精确评估pCR方面存在局限性.

研究的目的:

评估68Gallium纤维细胞激活蛋白抑制剂 (68Ga-FAPI) PET/CT与MAMMI PET结合的诊断性能,用于评估乳腺癌患者的PCR到NACT.
为了比较68Ga-FAPI PET/CT和68Ga-FAPI MAMMI PET与18F-FDG PET/CT和MRI用于残留瘤检测的实用性.

主要方法:

20名接受NACT和治疗前/后PET/CT成像 (18F-FDG,68Ga-FAPI,68Ga-FAPI MAMMI PET) 的女性乳腺癌患者的回顾性审查.
放射学和组织病理学数据与成像发现相关.
用接收器操作特征 (ROC) 分析来评估诊断性能,并分析了诸如瘤背景率 (TBR) SUVmax等定量参数.

主要成果:

定量68Ga-FAPI MAMMI PET TBR SUVmax在乳腺残留瘤检测方面表现出高的诊断性能 (91%的灵敏度,80%的特异性,86%的准确性).
与18F-FDG PET/CT和MRI相比,68Ga-FAPI PET/CT显示出更好的灵敏度和准确性,用于检测关疾病,尽管灵敏度仍然有限.
多变量分析确定了定量68Ga-FAPI MAMMI PET参数作为治疗反应的显著预测指标.

结论:

定量68Ga-FAPI PET/CT与MAMMI PET相结合,在乳腺中确定pCR的诊断性能比现有方法更高.
这些新型PET标记物用于检测残留关疾病的灵敏度需要进一步改进和在更大的队列中验证.
需要对更大患者群进行进一步的研究,以优化68Ga-FAPI PET/CT在乳腺癌治疗反应评估中的作用.

关键词:

18F-FDG 关于PET/CT 的研究 68Ga-FAPI PET/CT 是一个可靠的方法.咪的物物乳腺癌乳腺癌乳腺癌新辅助性化疗是一种新辅助性化疗.

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