对精神分裂症中长非编码RNA的遗传和功能性见解
Xinglun Dang1, Daohua Gong1, Shan-Shan Dai1
1Department of Psychiatry and Psychosomatics, Zhongda Hospital, State Key Laboratory of Digital Medical Engineering, School of Medicine, Advanced Institute for Life and Health, Jiangsu Provincial Key Laboratory of Brain Science and Medicine, Southeast University, Nanjing, Jiangsu, 210096, China.
Molecular psychiatry
|December 14, 2025
概括
这项研究确定了与精神分裂症 (SCZ) 风险相关的长非编码RNA (lncRNAs). lncRNA LINC01068 影响神经发育和突触通路,这表明它在SCZ病变发生过程中的作用.
科学领域:
- 神经科学是一个神经科学.
- 遗传学 是一个遗传学.
- 分子生物学分子生物学
背景情况:
- 长非编码RNAs (lncRNAs) 是大脑发育和功能中的关键调节者.
- 在精神分裂症 (SCZ) 中观察到失调的lncRNA表达,但潜在的遗传原因和功能影响尚不清楚.
研究的目的:
- 系统地识别和描述与SCZ相关的lncRNAs.
- 研究SCZ相关 lncRNAs的遗传基础和生物后果.
- 在神经干细胞中功能验证候选lncRNA,LINC01068.
主要方法:
- 从SCZ病例和对照中对大脑组织进行转录组分析 (LIBD2研究).
- 表达量的特征位置 (eQTL) 分析,将遗传变异与lncRNA表达联系起来.
- 整合eQTL数据与SCZ全基因组关联研究 (GWAS).
- 在人体神经干细胞 (hNSCs) 中LINC01068的体外功能测试 (敲击) 和转录基因分析.
主要成果:
- 在SCZ大脑中鉴定出明显失调的lncRNAs.
- 在人类大脑中发现了与lncRNA表达相关的遗传变异.
- 与SCZ风险相关的基因调节的lncRNA表达变化.
- 证明LINC01068的淘汰会影响hNSC的扩散,迁移和分化.
- 显示LINC01068调节SCZ相关基因和突触通路.
结论:
- 这项研究系统地描述了SCZ相关的lncRNA,突出了它们的遗传和功能相关性.
- 通过影响神经发育和突触通路,LINC01068与SCZ风险有关.
- 这些发现为lncRNAs在精神分裂症中的作用提供了关键的遗传和功能见解.
相关概念视频
lncRNA - Long Non-coding RNAs
9.7K
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
9.7K
lncRNA - Long Non-coding RNAs
3.5K
3.5K
Types of RNA
8.9K
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA Performs Diverse...
RNA Performs Diverse...
8.9K
Types of RNA
72.4K
Overview
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA...
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA...
72.4K
Biological Causes of Schizophrenia
464
Schizophrenia, a severe psychiatric disorder, arises from a complex interplay of biological factors, including genetic predisposition, structural brain abnormalities, neurotransmitter dysregulation, and developmental irregularities. These factors collectively contribute to the onset and progression of the disorder, which typically manifests in late adolescence or early adulthood.
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
464
Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders
1.8K
Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
1.8K


