自闭症谱系障碍的负担和风险因素:全球研究和分析
Lin Lin1,2,3, Yunge Zhang2, Dongyue Zhou2
1Women and Children's Hospital of Dalian University of Technology, Dalian, Liaoning Province, China.
Pediatric research
|December 14, 2025
概括
全球自闭症谱系障碍 (ASD) 率正在上升,亚太地区高收入国家负担最高. 研究表明,自闭症风险与大脑,代谢和肠道因素之间存在潜在联系,有助于未来的预防和诊断.
科学领域:
- 神经科学是一个神经科学.
- 遗传学 是一个遗传学.
- 公共卫生 公共卫生
背景情况:
- 自闭症谱系障碍 (ASD) 的患病率在全球范围内不断增加.
- 了解ASD模式和促成因素至关重要.
研究的目的:
- 分析1990-2021年全球ASD趋势,并预测到2030年.
- 使用孟德尔随机化 (MR) 调查ASD和生物因素之间的潜在因果关系.
主要方法:
- 利用2021年全球疾病负担数据进行趋势分析.
- 采用孟德尔的随机化 (MR) 来探索与神经,代谢和肠道微生物群因素的关联.
主要成果:
- 在高收入亚太国家,特别是日本,观察到最高的年龄标准化残疾调整寿命年 (DALY) 率.
- 预计到2030年,全球自闭症负担 (DALYs) 将增加近59%,这是人口增长所推动的.
- 核磁共振分析表明,ASD风险与特定的大脑区域,代谢物质 (例如,硫二) 和肠道细菌 (例如,Bacteroides) 之间的潜在联系.
结论:
- 在全球范围内,自闭症负担存在显著的差异,显著集中在高收入的亚太地区.
- 预计全球自闭症残疾人人数的增加凸显了一个迫切的公共卫生挑战.
- 确定了潜在的可修改因素 (神经,代谢,肠道),为改善ASD预防,早期诊断和干预策略提供了途径.
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