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RNA-seq

RNA-seq

RNA sequencing, or RNA-Seq, is a high-throughput sequencing technology used to study the transcriptome of a cell. Transcriptomics helps to interpret the functional elements of a genome and identify the molecular constituents of an organism. Additionally, it also helps in understanding the development of an organism and the occurrence of diseases.
Before the discovery of RNA-seq, microarray-based methods and Sanger sequencing were used for transcriptome analysis. However, while...

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Updated: Jan 8, 2026

De novo Identification of Actively Translated Open Reading Frames with Ribosome Profiling Data

De novo Identification of Actively Translated Open Reading Frames with Ribosome Profiling Data

Published on: February 18, 2022

Alignoth:阅读对齐的便携式和交互式可视化.

Felix Wiegand¹, Felix Mölder^1,2, Johannes Köster¹

¹Bioinformatics and Computational Oncology, Institute for AI in Medicine (IKIM), University Hospital Essen, University of Duisburg-Essen, Essen 45131, Germany.

Bioinformatics (Oxford, England)

|December 14, 2025

概括

此摘要是机器生成的。

Alignoth是一个新的命令行工具,可以创建便携式HTML报告,用于DNA测序对齐堆积. 这些报告具有轻量级,可搜索,并可导出到各种静态格式,以方便共享和集成.

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Informatic Analysis of Sequence Data from Batch Yeast 2-Hybrid Screens

Informatic Analysis of Sequence Data from Batch Yeast 2-Hybrid Screens

Published on: June 28, 2018

相关实验视频

Last Updated: Jan 8, 2026

De novo Identification of Actively Translated Open Reading Frames with Ribosome Profiling Data

De novo Identification of Actively Translated Open Reading Frames with Ribosome Profiling Data

Published on: February 18, 2022

Optimization of Synthetic Proteins: Identification of Interpositional Dependencies Indicating Structurally and/or Functionally Linked Residues

Optimization of Synthetic Proteins: Identification of Interpositional Dependencies Indicating Structurally and/or Functionally Linked Residues

Published on: July 14, 2015

Informatic Analysis of Sequence Data from Batch Yeast 2-Hybrid Screens

Informatic Analysis of Sequence Data from Batch Yeast 2-Hybrid Screens

Published on: June 28, 2018

科学领域:

生物信息学是一种生物信息学.
计算生物学计算生物学
基因组学就是基因组学.

背景情况:

DNA 测序产生了大量的数据集,需要高效的分析.
可视化读取对齐堆积对于基因组数据解释至关重要.
现有的工具可能缺乏可移植性或交互功能,用于对齐可视化.

研究的目的:

介绍Alignoth,一个新的命令行应用程序,用于生成DNA测序对齐报告.
为可视化阅读对齐堆积提供轻量级和便携式解决方案.
加强基因组分析结果的共享和整合.

主要方法:

开发了Alignoth作为使用Rust编程语言的命令行应用程序.
实现了用于生成独立,便携式HTML报告的功能.
启用了对静态格式 (PNG,SVG,PDF) 和JSON的导出功能.

主要成果:

艾利诺斯 (Alignoth) 制作HTML报告,具有互动功能,如读取名称搜索和映射质量的突出显示.
报告的存储要求最小,方便实际共享.
该应用程序支持无头环境生成,并提供后期的交互式检查.

结论:

Alignoth提供了一种实用且高效的方法来报告DNA测序对齐堆积.
它的可移植性和出口选项使其对各种报告工作流程具有价值.
该工具增强了基因组对齐数据可视化的可访问性和可用性.