综合转录基因和微生物群分析揭示了与Nibea coibor养策略有关的与生长相关的肠道反应
Zhaoqiu Qu1, Jiayu Zhou1, Ruojing Li1
1Southern Marine Science and Engineering Guangdong Laboratory-Zhanjiang, Zhanjiang, 524025, China.
Advanced biotechnology
|December 14, 2025
概括
间歇性禁食 (IF) 通过增强肠道微生物群和形态来促进养殖鱼的肠道健康. 连续禁食 (CF) 损害了鱼的肠道完整性,而夜间食 (NF) 显示出最小的影响,突出IF作为优越的食策略.
科学领域:
- 水产养殖是水产养殖的一种方式.
- 鱼类生理学 鱼类生理学
- 微生物组研究 微生物组研究
背景情况:
- 食策略对于养殖鱼的肠道健康至关重要,但监管机制尚不清楚.
- 尼贝,一种海洋鱼,被用来研究食对肠道平衡的影响.
研究的目的:
- 对肠道形态,转录组和微生物群中的养策略的调节网络进行剖析.
- 为了比较白天食 (DF),连续禁食 (CF),间歇禁食 (IF) 和夜间食 (NF) 的效果.
主要方法:
- 综合的多omics分析 (转录组,微生物群).
- 肠道形态的组织学检查.
- 对于监管关系的部分最小平方路径建模 (PLS-PM).
主要成果:
- 养策略显著改变了肠道微生物群和基因表达.
- 连续禁食 (CF) 导致状缩,杯状细胞丧失和微生物失生症.
- 间歇性禁食 (IF) 优化了肠道健康,增加了杯状细胞密度,毛高度和微生物多样性.
- 夜间养 (NF) 对能量代谢基因产生轻微影响,短期生理节律影响有限.
结论:
- 间歇性禁食 (IF) 是通过微生物群与宿主协同作用来维持肠道平衡的一个有希望的策略.
- 长时间的禁食可能会导致代谢和屏障功能障碍.
- 研究结果为优化海洋鱼类水产养殖中的养方案提供了见解,特别是对于Nibea coibor.
相关概念视频
Bacterial Flora of the Large Intestine
1.5K
The gut microbiome is formed by a vast and diverse community of bacteria that colonizes our large intestine. These bacteria start residing in the gut from birth and continue diversifying throughout life, influenced by factors such as diet, lifestyle, and stress. The gut bacterial community also includes bacteria from food and those that enter the colon through the anus.
The normal gut flora of the colon plays a critical role in generating essential vitamins such as vitamins K, B5, and B7.
The normal gut flora of the colon plays a critical role in generating essential vitamins such as vitamins K, B5, and B7.
1.5K
Anatomy of the Intestines
86.5K
Although digestion of proteins, carbohydrates, and lipids may begin in the stomach, it is completed in the intestine. The absorption of nutrients, water, and electrolytes from food and drink also occurs in the intestine. The intestines can be divided into two structurally distinct organs—the small and large intestines.
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
86.5K
Microbial Nutrition
1.0K
Organisms exhibit remarkable metabolic diversity, categorized based on how they acquire energy and carbon. These strategies enable survival in various ecological niches and are essential for maintaining energy flow and nutrient cycling within ecosystems.Energy and Carbon SourcesOrganisms are classified as phototrophs or chemotrophs based on energy acquisition. Phototrophs use light as their energy source, while chemotrophs rely on oxidizing chemical compounds. Further differentiation arises...
1.0K
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
614
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
614


