脂肪肝指数和功能之间的横截面和纵向关联使用更新的MASLD和CKD-EPI 2021定义:以人口为基础的研究,具有特定区域的切断值
Sina Bazmi1,2, Mohammadreza Fardaei2, Reza Homayounfar1,3
1Noncommunicable Diseases Research Center, Fasa University of Medical Sciences, Fasa, 6688-8-74616, Iran.
European journal of medical research
|December 14, 2025
概括
与代谢功能障碍相关的脂肪性肝病 (MASLD) 和较高的脂肪肝指数 (FLI) 与更差的功能有关. 使用特定区域的切断值可以改善慢性病 (CKD) 风险的识别.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 肝病学 肝病学是一种肝病学.
- 代谢综合征是代谢综合征的一种.
背景情况:
- 与代谢功能障碍相关的脂肪性肝病 (MASLD) 影响脏健康.
- 脂肪肝指数 (FLI) 和估计的球过率 (eGFR) 的关系需要进一步调查.
- 慢性病 (CKD) 是肝硬化症的显著并发症.
研究的目的:
- 检查FLI和eGFR之间的横截面和纵向关联.
- 通过更新的定义来评估MASLD和CKD之间的关系.
- 为了比较特定区域的FLI截止值与CKD风险预测的标准值.
主要方法:
- 分析了来自Fasa成人队列研究 (FACS) 的9,911名成年人,其中2,906人进行了5年的随访.
- 使用性别特异性,区域验证的截止值计算FLI,并通过2021年CKD-EPI方程估计eGFR.
- 回归模型和散射图用于评估FLI-eGFR和MASLD-CKD关联,经过调整以考虑混因素,并进行子组和灵敏度分析.
主要成果:
- MASLD与58%更高的CKD横截面概率有关. 每增加10个单位的FLI与eGFR的2.4mL/min/1.73m2下降相关.
- 从长度来看,更高的FLI预测了更大的eGFR下降,而MASLD增加了CKD风险,特别是在男性中.
- 特定区域的FLI切线比欧洲FLI ≥60值产生了更稳定的纵向关联.
结论:
- 较高的FLI和MASLD与功能受损有关,无论是横截面还是前性.
- 人口校准的FLI指数对于稳定的纵向CKD风险评估至关重要.
- 在MASLD患者中,FLI显示出作为早期CKD风险识别的可扩展工具的潜力.
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