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三甘油糖指数及其修改指数的比较,用于预测晚期CLKM综合征的死亡率

Jiahua Liang¹, Huamei Li¹, Yueqiao Zhong¹

¹Meizhou Hospital of Guangzhou University of Chinese Medicine, Meizhou, Guangdong, China.

Journal of health, population, and nutrition

|December 14, 2025

概括

甘油三糖 (TyG) 指数及其变体显示了U形的关联与晚期心血管肝代谢综合征 (CLKM) 的死亡率. 原始的TyG指数是一种可比且更简单的工具,用于CLKM患者的风险分层.

科学领域:

心血管疾病是什么心血管疾病
代谢综合征是代谢综合征.
临床流行病学临床流行病学

背景情况:

三甘-葡萄糖 (TyG) 指数及其在先进心血管-肝脏-脏-代谢综合征 (CLKM) 的死亡率方面的人类测量增强变体的预后价值尚未得到充分理解.
肺结核瘤是一种复杂的多系统疾病,影响心脏,肝脏,脏和代谢健康.

研究的目的:

调查TyG指数及其修改变体 (TyG-WC,TyG-WHtR,TyG-BMI) 与晚期CLKM综合征的成年人全因死亡率之间的关联.
为了比较原始TyG指数的预测性表现与其人体测量增强版本的死亡风险.

主要方法:

一项全国范围的前性队列研究利用了1384名患有晚期CLKM综合征的成年人的数据 (NHANES 1999-2018).
权重多变量考克斯比例危险模型和限制立方线 (RCS) 用于评估关联并确定非线性关系.
使用C指数,净重新分类指数 (NRI) 和综合歧视改进 (IDI) 进行了预测性绩效的比较.

主要成果:

在平均56个月的随访期间,发生了360例死亡.
RCS揭示了TyG指数和死亡率之间的U形关联,TyG,TyG-WC,TyG-WHtR和TyG-BMI的转折点被确定.
原始TyG指数的预测性能与其修改变体的预测性能相似,死亡率预测没有显著改善.

结论:

泰格指数在晚期CLKM综合征中与死亡率呈现U形的关联,表明双重代谢作用.
原始的TyG指数作为一种节且有效的工具,用于在这一群体中的风险分层.
已识别的转折点为个性化管理策略提供了潜在的门.

关键词:

所有原因的死亡率.心血管肝脏代谢综合征修改后的甘油三糖指数三甘油糖指数是指三甘油糖指数.

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