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COVID-19的汗水印记:独特的代谢物签名

Snehal Bhumkar¹, Manjari Jonnalagadda², Khushman Taunk³

¹Department of Zoology, Savitribai Phule Pune University, Pune, India.

Biomarkers in medicine

|December 15, 2025

概括

研究人员确定了SARS-CoV-2感染的独特的汗液代谢物签名. 在有症状的个体中,特定的基和衍生物显著升高,这表明了不同的代谢概况.

科学领域:

代谢学代谢学代谢学
生物化学生物化学
传染病诊断传染病诊断传染病诊断

背景情况:

人的汗水分析提供了对新陈代谢过程的洞察.
像SARS-CoV-2这样的呼吸道感染可以通过独特的代谢物签名改变身体气味.

研究的目的:

为了识别明显的汗液代谢物签名,表明SARS-CoV-2感染.
在流行病浪潮期间分析汗液代谢物以寻找独特的感染生物标志物.

主要方法:

在SARS-CoV-2流行浪潮期间从有症状,无症状和健康个体收集了下汗液样本.
使用气相色谱-质谱法 (GC-MS) 进行代谢物分析.
使用主要组件分析 (PCA) 和部分最小方程差异分析 (PLS-DA) 进行群体歧视.

主要成果:

通过PCA和PLS-DA观察到不同的样本组集群.
在受感染的个体中发现了六种特定化合物,包括基 (如6 - 乙基 - 2 - 甲基,四甲基) 和其他物质 (烯,2 - 乙基 - 1 - 赫桑醇,2 - 甲基,1 - 乙氧).
在有症状的队列中,基和衍生物的含量显著增加.

结论:

对于有症状的SARS-CoV-2个体,有一个独特的汗液代谢物概况.
汗液中基的升高与与SARS-CoV-2感染相关的炎症性肺部疾病有关.

关键词:

这就是SARS-CoV-2病毒.生物标志物生物标志物气相色谱是一种气相色谱.人的汗水是人类的汗水.质谱测量质谱测量质谱测量质谱测量质量测量质谱测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量质量测量代谢生物组的代谢生物组不侵入式检测SARS-CoV-2病毒的方法挥发性有机化合物挥发性有机化合物

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