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GERD和上空消化道癌症风险:系统性审查和元分析
Janice Huang1, Nicolas Jo2, Garret Forman1
1Department of Otolaryngology, University of Miami, Miami, Florida, USA.
The Laryngoscope
|December 15, 2025
概括
胃食道逆流性疾病 (GERD) 增加了喉癌的风险. 这项研究量化了GERD的数量.
科学领域:
- 胃肠道学和瘤学
- 癌症的流行病学 癌症的流行病学
- 上空消化道 (UADT) 恶性瘤
背景情况:
- 胃食道逆流性疾病 (GERD) 是一个常见的疾病.
- GERD与上空消化道癌 (UADT) 之间的联系,不包括食道腺癌,需要进一步澄清.
- 了解这些关联对于风险分层和早期检测至关重要.
研究的目的:
- 系统地审查和元分析观察性研究.
- 量化GERD和特定UADT癌症之间的关联.
- 为了排除与食道腺癌的已确立联系.
主要方法:
- 在2000-2024年期间,对主要数据库 (PubMed,Embase,Scopus,Cochrane,CINAHL) 进行全面的文献搜索.
- 包括关于GERD和UADT癌症 (不包括食道腺癌) 的队列和病例控制研究.
- 使用纽卡斯尔-太华规模的质量评估和使用随机效应模型的元分析来计算聚合相对风险 (RR) 和95%置信区间 (CI).
主要成果:
- 包括17项研究,涉及近180万参与者.
- 在GERD和喉癌之间发现了显著的关联 (RR = 1.65,95% CI = 1.19-2.31).
- 对于,口,鼻或食道状细胞癌,没有观察到显著的关联.
结论:
- 胃食道逆流性疾病 (GERD) 与喉癌的风险增加有关.
- 这些发现凸显了反流在UADT致癌过程中的潜在作用.
- 需要进一步的研究,特别是在高风险人群中.
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