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Updated: Jan 8, 2026

Irradiator Commissioning and Dosimetry for Assessment of LQ α and β Parameters, Radiation Dosing Schema, and in vivo Dose Deposition
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评估长效注射产品等离子体暴露的基于模型的推断:从单剂量到多剂量试验

D Esther Lubberts1,2, Douglas J Eleveld1, Laurens F M Verscheijden2,3

  • 1Department of Anesthesiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.

CPT: pharmacometrics & systems pharmacology
|December 15, 2025
PubMed
概括

通过使用单剂量药理动力学数据,可以开发预测多剂量后长效注射剂 (LAI) 释放药物的模型. 这表明药物释放可能在已批准的LAI单剂和多剂条件之间相似.

关键词:
生物等价性 生物等价性建模 建模模型 建模模型基于模型的药物开发.药物动力学 药物动力学药学指标 药学指标 药学指标人口的药理动力学监管部门的监管机构.模拟模拟是指一个模拟模拟.

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