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父母暴露于本佐[a]烯会影响骨质母细胞亚群中的组织蛋白修饰

Alexis S Trujillo¹, Remi O Labeille¹, Rijith Jayarajan¹

¹Texas A&M University-Corpus Christi, Department of Life Sciences, 6300 Ocean Drive, Corpus Christi, TX 78412, United States.

Environmental epigenetics

|December 15, 2025

概括

父母暴露于[a]烯 (BaP) 改变了发展骨质母细胞的关键组织蛋白修饰,影响了骨的形成. 基因组蛋白中的这些环境诱导的表观遗传变化是跨代可遗传的.

科学领域:

环境表观遗传学环境表观遗传学
发展生物学发展生物学
毒理学毒理学毒理学

背景情况:

环境压力因素,如[a]pyrene (BaP) 与后代发育骨缺陷有关.
质子修饰 (H3K4me3,H3K9me3,H3K27me3,H3K27ac,H4K5ac/K8ac/K12ac) 对于骨质细胞的分化至关重要.

研究的目的:

为了研究父母的BaP暴露对梅达卡骨质细胞 (Oryzias latipes) 的基质子代码的影响.
量化环境污染物干扰染色体结构调节及其对骨健康的跨代影响.

主要方法:

使用了一种转基因的梅达卡菌株 (twist:dsred/col10a1:gfp),有或没有父母的BaP暴露.
在骨质母细胞亚群中 (twist+和col10a1+) 通过免疫光检测评估了特定的组织蛋白修饰 (H3K9me3,H4K5ac/K8ac/K12ac).

主要成果:

父母暴露于BaP显著减少了H3K9me3标记在双性双性的twist+细胞中.
在暴露于BaP后,雄性鱼在col10a1+细胞中的H3K9me3和H4K5ac/K8ac/K12ac显著减少.
在骨质母细胞亚群中观察到明显的基因组修饰模式的性别特异.

结论:

骨质母细胞中BaP诱导的组织蛋白修饰是遗传的,并以特定亚种群的方式影响骨形成.
了解这些表观遗传变化对于评估BaP污染的生态和公共卫生风险至关重要.

关键词:

表观遗传学是指表观遗传学.基因组蛋白质的概况基因组蛋白质的概况骨质母细胞亚种群.性别差异的性别差异.跨代性毒性跨代性毒性

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