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基于扩散模型的OCT到OCTA翻译
Rashadul Hasan Badhon1, Atalie Carina Thompson2, Jennifer I Lim3
1Department of Electrical and Computer Engineering, University of North Carolina at Charlotte, Charlotte, NC, United States.
Frontiers in medicine
|December 15, 2025
概括
一个新的棕色桥扩散模型 (BBDM) 将光学连贯断层扫描 (OCT) 图像转换为OCT血管图像 (OCTA). 这种方法提高了视网膜疾病诊断的结构忠实性和临床实用性.
科学领域:
- 医疗成像医学成像
- 人工智能的人工智能
- 眼科医生 眼科 眼科
背景情况:
- 光学连贯断层扫描 (OCT) 对于视网膜成像至关重要.
- OCT血管造影 (OCTA) 提供了重要的血管信息,但需要专门的设备.
- 将OCT翻译为OCTA可以提高可访问性,并降低诊断视网膜疾病的成本.
研究的目的:
- 引入一种新的基于条件扩散的方法,棕色桥扩散模型 (BBDM),用于从OCT到OCTA的图像转换.
- 解决传统的生成对抗网络 (GAN) 在概括和结构忠实性方面的局限性.
- 评估BBDM在从OCT图像生成OCTA方面的临床实用性和性能.
主要方法:
- 开发并实施了使用双向随机过程的布朗桥扩散模型 (BBDM).
- 在VQGAN的潜伏空间内集成的BBDM用于训练.
- 在OCT500数据集上训练模型,并在UIC的糖尿病视网膜病变患者的临床数据集上验证.
主要成果:
- 与GAN相比,BBDM在结构相似性指数 (SSIM) 和感知对比质量指数 (PCQI) 中表现优异,特别是在更大的视野扫描中.
- 该模型保持了与基本真相OCTA一致的解剖学趋势,并保留了临床相关的血管特征 (BVC,BVT,VPI).
- 虽然BBDM在FID等一些指标上显示了微小的偏差,但在计算简单性,训练稳定性和减少图像幻觉方面提供了优势.
结论:
- BBDM代表了第一个基于传播的OCT-to-OCTA翻译框架.
- 该模型成功地从标准的OCT图像中生成了具有临床意义的OCTA.
- 这种方法支持对视网膜疾病进行更容易获得和更具成本效益的诊断.
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