在患有注意力缺陷/多动障碍的儿童中,与情绪失调相关的异常功能连接性
Sixun Li1,2, Tingting Luo1,2, Meiwen Wang1,2
1Child Mental Health Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Frontiers in psychiatry
|December 15, 2025
概括
患有注意力缺陷/多动障碍 (ADHD) 和情绪失调 (ED) 的儿童表现出不同的大脑连接模式. 这些在患有ED的ADHD儿童中的发现可能会为早期识别和有针对性的干预提供信息.
科学领域:
- 神经科学是一个神经科学.
- 发展心理学 发展心理学
- 儿童精神病学 儿童精神病学
背景情况:
- 情绪失调 (ED) 在患有注意力缺陷/多动障碍 (ADHD) 的儿童中普遍存在,加剧了学术,社会和生活质量损害.
- 在ADHD中ED的神经生物学基础仍然不完全理解,需要对大脑功能连接进行进一步的研究.
研究的目的:
- 探索ADHD和ED儿童的不同功能连接模式.
- 将这些模式与没有ED的ADHD儿童和典型发育控制 (TDC) 进行比较.
主要方法:
- 招募了77名患有ED的ADHD,53名没有ED的ADHD和55名TDC进行临床评估和休息状态功能性MRI.
- 利用以种子为基础的分析,专注于背侧前额叶皮层 (DLPFC) 和杏仁体,随后进行休息状态功能连接 (RSFC) 分析.
- 使用ANCOVA和后期测试进行群组比较和Pearson相关性,以评估RSFC和ED严重程度之间的关系.
主要成果:
- 患有ED的ADHD组在DLPFC和轨道前皮层 (OFC) /前之间增加了RSFC,在DLPFC和下额 (IFG) 之间减少了RSFC.
- 在患有ED的ADHD患者中,在杏仁体和头/中后环之间也观察到RSFC降低.
- DLPFC和OFC之间的RSFC与ED症状严重程度在ADHD与ED组中负相关.
结论:
- 在患有ED的多动症儿童中,DLPFC-OFC和桃体-骨区域之间存在异常的功能连接.
- 这些发现为ED的ADHD早期识别策略提供了理论支持.
- 已识别的连接模式可能成为未来神经调节干预的潜在目标.
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