根据生活方式和精子质量构建ICSI-ET辅助生殖结果的诺姆图:多中心回顾性调查
Ke Wang1,2, Shihui Wang3, Yan Xu2
1Center of Reproductive Medicine, Shanghai Key Laboratory of Maternal Fetal Medicine, Shanghai Institute of Maternal-Fetal Medicine and Gynecologic Oncology, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai, China.
Frontiers in endocrinology
|December 15, 2025
概括
生活方式和精子质量是怀孕成功的关键因素,不孕男性接受细胞内质精子注射 (ICSI). 一个新的名图准确地预测了结果,为ICSI-ET周期提供了个性化治疗和咨询.
科学领域:
- 生殖医学 生殖医学
- 安德罗学与人类学
- 生物统计学 生物统计学
背景情况:
- 内细胞质精子注射 (ICSI) 是男性不孕症的关键辅助生殖技术.
- 在ICSI新鲜胚胎移植 (ICSI-ET) 周期中预测临床妊娠结果仍然具有挑战性.
- 识别有影响力的风险因素对于优化治疗策略至关重要.
研究的目的:
- 为了确定影响临床怀孕结果的风险因素,不孕男性接受ICSI.
- 开发和验证一个名ogram预测模型,以确保ICSI-ET的成功.
主要方法:
- 一项回顾性研究包括1,037名接受ICSI-ET的不育男性.
- 使用拉索和多变量逻辑回归分析来选择预测因素并构建名ogram.
- 外部验证是使用290名其他患者的数据进行的.
主要成果:
- 确定的主要预测因素包括年龄,BMI,吸烟,饮酒,睡眠,运动,压力,精子运动性和DNA碎片化.
- 诺米图表显示出高预测准确度,在训练组中AUC为0.919,在外部验证组中为0.918.
- 该模型显示出强烈的区分和校准,在培训和验证队列中具有高准确性,灵敏性和特异性.
结论:
- 精子质量和生活方式因素显著影响不孕男性的ICSI-ET怀孕结果.
- 开发的诺米图是预测ICSI成功的可靠工具.
- 这种工具可以帮助临床医生为不育患者提供个性化咨询和有针对性的干预措施.
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