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Transcranial Pulse Stimulation for Alzheimer's Patients
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在轻度至中度阿尔茨海默氏症的治疗中使用氏
Anton P Porsteinsson1, Marwan Sabbagh2, Pierre N Tariot3
1Alzheimer's Disease Care, Research and Education Program(AD-CARE), Department of Psychiatry, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA.
Journal of Alzheimer's disease reports
|December 15, 2025
概括
在2/3期试验中,氏并没有显著改善阿尔茨海默病的症状. 然而,该药物表现出潜在的相关生物活性和可接受的安全性,这需要进一步研究高基因路调节.
科学领域:
- 神经科学是一个神经科学.
- 药理学 药理学是指药理学的学科.
- 临床试验 临床试验
背景情况:
- 福斯戈尼梅顿是一种小分子正模拟器的神经营性肝细胞生长因子 (HGF) 系统.
- 阿尔茨海默病 (AD) 是一种进展性神经退行性疾病,其特点是认知能力下降.
研究的目的:
- 为了评估fosgonimeton在患有轻度至中度阿尔茨海默病的参与者的疗效和安全性.
- 评估福斯戈尼梅顿对认知和功能终点以及生物标志物的影响.
主要方法:
- 一个随机的,安慰剂对照的2/3期试验 (LIFT-AD) 涉及287名患有轻度至中度AD的参与者.
- 参与者每天接受皮下格尼美顿 (40毫克) 或安慰剂,没有同时服用乙胆酶抑制剂.
- 主要终点是全球统计测试 (GST) 成绩;次要终点包括ADAS-Cog11,ADCS-ADL23和NfL水平.
主要成果:
- 该试验没有达到其初级或二级终点,在fosgonimeton和安慰剂组之间没有显著差异.
- 在ADAS-Cog11和ADCS-ADL23.23中观察到有利于fosgonimeton的小而无意义的改善.
- 福斯贡尼梅顿显示出可接受的安全性概况,严重的不良事件在各组之间保持平衡;然而,在福斯贡尼梅顿组中,更多的参与者因副作用而停止治疗.
结论:
- 在阿尔茨海默氏症患者中,氏并没有显著改善认知或功能结果.
- 观察到的非显著的趋势表明了fosgonimeton的潜在生物活性,表明HGF通路调节可能会影响神经退行过程.
- 进一步的研究可能会探索HGF通路调节在神经退行性疾病中的治疗潜力.
关键词:
阿尔茨海默病的疾病阿尔茨海默病的疾病.乙胆化酶抑制剂 乙胆化酶抑制剂日常生活中的日常生活活动.生物标志物 生物标志物临床试验/研究.认知评估是一种认知评估.福斯哥尼米顿是一个形的物质.全球统计测试全球统计测试神经保护性神经保护剂这是一种神经缩性神经营养.更多相关视频
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