塞马格卢提德或提尔泽帕提德治疗与胃部残留物之间的关联:在上部内镜检查过程中存在潜在危险
Jimmy Wen1, Jose Puglisi2, Eldo Frezza3
1Physical Medicine and Rehabilitation, California Northstate University College of Medicine, Elk Grove, USA.
Cureus
|December 15, 2025
概括
长期使用西马格卢提德/蒂尔泽帕提德 (GLP-1) 增加了残留胃含量 (RGC) 在EGD之前的风险,即使是禁食. 这一发现对于内镜手术期间的患者安全至关重要.
科学领域:
- 胃肠病学 胃肠病学
- 内分泌学 在内分泌学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 塞马格卢提德和蒂尔泽帕提德是用于2型糖尿病和肥胖症的葡萄糖类-1 (GLP-1) 受体激动剂.
- GLP-1激动剂可以减缓胃排空,可能增加残留胃含量 (RGC) 的风险.
- 消化管-胃-门视镜 (EGD) 需要空腹才能确保安全性和诊断准确性.
研究的目的:
- 为了评估在接受EGD的患者服用半黄或铁泽帕提德的胃残留含量 (RGC) 的风险.
- 评估GLP-1使用时间和RGC存在之间的关联.
- 在这个患者群体中确定RGC的潜在风险因素.
主要方法:
- 对144名接受EGD的患者进行了回顾性观察性研究.
- 患者根据使用西马格卢提德/蒂尔泽帕提德和使用时间 (> 6 个月 vs < 6 个月) 进行了分类.
- 统计分析包括费舍尔的精确测试,斯皮尔曼的相关性和菲尔斯的后勤回归来评估RGC和相关因素.
主要成果:
- 在12名患者中有11名 (91.7%) 接受了六个多月的塞马格卢提德/蒂尔泽帕提德治疗,有RGC.
- 在GLP-1使用>6个月和RGC存在 (p<0.001) 之间发现了显著的关联.
- RGC显示与年龄的中度积极关联,与BMI的微弱负面关联;没有出现与程序相关的并发症.
结论:
- 六个月以上使用西马格卢提德/蒂尔泽帕提德与EGD之前的胃残留含量 (RGC) 的显著风险有关.
- 尽管遵守标准的禁食协议,这种风险仍然存在.
- 长期接受GLP-1治疗的患者的内镜手术需要仔细考虑胃内容.
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