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细胞因子释放综合征:一个病例报告

Inês Filipa Silva¹, Sofia Gomes Salgueira¹, Ana Isabel Loureiro¹

¹Pulmonology Department, Unidade Local de Saúde de Trás-os-Montes e Alto Douro, Vila Real, PRT.

|December 15, 2025

概括

免疫检查点抑制剂可能导致细胞因子释放综合征 (CRS),严重的免疫反应. 在接受这些疗法的患者中,早期识别和皮质类固醇治疗对于管理CRS至关重要.

科学领域:

在瘤学瘤学.
免疫学免疫学免疫学
药理学药理学是指药理学的学科.

背景情况:

免疫检查点抑制剂 (ICI),如 pembrolizumab 在癌症治疗中至关重要.
严重的免疫相关不良事件,包括细胞因子释放综合征 (CRS),可以发生在ICI.
细胞因子释放综合征涉及过度免疫激活和升高的介素-6 (IL-6) 水平.

研究的目的:

在接受 pembrolizumab 和 pemetrexed 维持治疗的患者中报告细胞因子释放综合征 (CRS) 的病例.
突出CRS的诊断挑战和有效管理.
强调皮质类固醇在治疗ICI诱导的CRS中的作用.

主要方法:

一个71岁的男性患有IVB期肺腺癌的病例报告.
在维持治疗期间,患者呈现急性混乱状态和发烧.
在排除其他原因后,CRS的诊断得到了高血清IL-6水平的支持.

主要成果:

患者表现出与CRS一致的症状,包括发烧和神经变化.
血清IL-6水平在270 pg/mL时显著升高.
系统性皮质类固醇治疗导致发烧和神经症状的缓解.

结论:

细胞因子释放综合征 (CRS) 是免疫检查点抑制剂的潜在严重不良事件.
早期诊断和及时管理,特别是用皮质类固醇,对于有利的结果至关重要.
这一案例强化了皮质类固醇在控制ICI诱导的CRS方面的疗效.

关键词:

临床病例报告细胞因子释放综合征细胞因子释放综合征对罕见病例的诊断.介质蛋白 (il) -6 的存在.互乐金-6是其中的一种.这就是Pembrolizumab.

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