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涉及单克隆B细胞淋巴细胞瘤的沃廷瘤:一个病例报告

Alexie Kindy¹, Ziang Wang², Robin Gautam³

¹College of Medicine, Northeast Ohio Medical University, Rootstown, USA.

|December 15, 2025

概括

一个Warthin的瘤,一种良性唾液腺生长,偶然地揭示了慢性淋巴细胞白血病 (CLL) 型单克隆B细胞淋巴细胞症 (MBL). 这一发现凸显了需要仔细评估基于突节外组织的MBL.

科学领域:

在瘤学瘤学.
病理学病理学病理学
免疫学免疫学免疫学

背景情况:

沃廷瘤是一种常见的良性唾液腺瘤.
它的特征是细胞上皮质和淋巴状层.
单克隆B细胞淋巴细胞症 (MBL) 是一种无症状的疾病,有进展为淋巴瘤的风险.

研究的目的:

报告在沃丁瘤中偶然发现慢性淋巴细胞白血病 (CLL) 类型的MBL.
强调在唾液腺瘤中免疫表型评估的重要性.
讨论基于外节组织的MBL的诊断标准.

主要方法:

切除术样本的组织学检查.
使用流细胞计 (CD5,CD23) 进行免疫表型分析.
在CLL和PET-CT成像中进行光 in situ杂交 (FISH).

主要成果:

鉴定出了一种经典的沃廷瘤.
在淋巴细胞层内检测到低水平 (8%-9%) CD5和CD23阳性B细胞群,与CLL型MBL一致.
没有发现明显淋巴瘤的形态证据,辅助测试没有显著的结果.

结论:

CLL类型的MBL可以发生在Warthin瘤的淋巴状层内.
仔细的组织学和免疫类型评估对于准确的诊断至关重要.
需要进行进一步的研究,以确定基于突节组织的MBL的明确诊断标准.

关键词:

慢性淋巴细胞白血病/小淋巴细胞淋巴瘤单克隆B细胞淋巴细胞病 (MBL)非霍奇金淋巴瘤非霍奇金淋巴瘤唾液腺瘤唾液腺瘤沃尔丁的瘤是一个瘤.

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