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对人类TMPRSS2的单克隆抗体可以防止任何SARS-CoV-2变种的感染

Michishige Harada¹, Takehisa Matsumoto², Mizuki Yamamoto³

¹Drug Discovery Antibody Platform Unit, RIKEN Center for Integrative Medical Sciences, Yokohama 230-0045, Japan.

|December 15, 2025

概括

针对跨膜血清蛋白酶2 (TMPRSS2) 的单克隆抗体有效地阻断了SARS-CoV-2的进入和复制在体外和体内. 这些TMPRSS2抗体为抗击COVID-19变种提供了有前途的治疗策略.

科学领域:

病毒学病毒学
免疫学免疫学免疫学
药物发现药物发现药物发现

背景情况:

跨膜血清蛋白酶2 (TMPRSS2) 对于SARS-CoV-2尖端蛋白原始化至关重要,促进病毒进入宿主细胞.
TMPRSS2是COVID-19治疗的验证治疗标.

研究的目的:

开发和评估针对人类TMPRSS2的单克隆抗体 (mAbs),用于针对SARS-CoV-2的治疗应用.
评估TMPRSS2 mAbs在抑制SARS-CoV-2感染中的疗效,在体外和体内.

主要方法:

对人类TMPRSS的单克隆抗体的建立2.
使用SARS-CoV-2感染细胞系和人类肺器官的mAb疗效的体外评估.
在人体ACE2/TMPRSS2-双重敲进小鼠和模型中的体内评估.

主要成果:

在包括Omicron在内的所有测试变种中,TMPRSS2 mAbs证明了对SARS-CoV-2感染的强有力的抑制.
mAbs的向性表位与活性部位不同,这表明它在不抑制蛋白酶活性的情况下对S蛋白-ACE2/TMPRSS2相互作用进行了固体阻断.
在体内研究表明,在接受治疗的动物中,病毒标位的显著抑制和肺炎的减少.

结论:

针对TMPRSS2的单克隆抗体是SARS-CoV-2感染的有效抑制剂.
这些针对TMPRSS2的mAbs代表了管理COVID-19的有希望的治疗途径,包括新兴变种感染.

关键词:

卫生科学卫生科学免疫学免疫学免疫学病毒学病毒学

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