慢性牙周炎和非酒精性脂肪肝疾病:关联机制的最新进展
Zhe Lyu1, Jieying Zhu2, Deying Chen3
1Department of Stomatology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, People's Republic of China.
International journal of general medicine
|December 15, 2025
概括
慢性牙周炎 (CP) 和非酒精性脂肪性肝病 (NAFLD) 是由全身炎症和失生症联系在一起的. 治疗牙周炎可能是NAFLD进展的可修改风险因素,强调口腔健康对肝脏健康的重要性.
科学领域:
- 胃肠病学和肝病学
- 口腔和牙面部外科手术
- 微生物学 微生物学
背景情况:
- 慢性牙周炎 (CP) 和非酒精性脂肪肝 (NAFLD) 是普遍存在的全球健康问题.
- 新出现的证据表明,这两种情况之间存在显著的关联,尽管潜在的机制需要进一步阐明.
- 本综述探讨了牙周炎和NAFLD之间的复杂联系,在口腔肠肝轴的框架内.
研究的目的:
- 系统地审查和综合有关牙周炎和NAFLD之间关联的现有证据.
- 阐明口腔健康与肝脏疾病之间的病理机制和相互作用.
- 确定牙周炎作为NAFLD的潜在可修改风险因素.
主要方法:
- 对观察性,干预性和机理学研究进行了全面的审查.
- 综合了证据,重点关注口腔 - 肠 - 肝轴组件:失调,炎症调解剂,微生物代谢物,氧化应激,微RNA和肠道屏障功能.
- 包括评估牙周状况和治疗对NAFLD结果的影响的研究.
主要成果:
- 流行病学研究表明牙周炎与NAFLD的风险和严重程度增加有关.
- 机械洞察力揭示了口腔失生症,微生物产品转移和全身炎症对肝硬化和纤维化有所贡献.
- 微生物代谢物,氧化应激和microRNA失调在代谢障碍和肝细胞损伤中起作用,尽管有关牙周炎治疗改善NAFLD的直接证据有限.
结论:
- 慢性牙周炎和NAFLD有共同的途径,包括系统性炎症,肠道失调和代谢功能障碍.
- 牙周炎被认为是影响NAFLD进展的可修改风险因素.
- 未来的研究和综合护理模型专注于微生物组调节和口腔肝脏健康对于预防和治疗至关重要.
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