生物膜的破坏增强了小肠细菌过度生长和肠道甲素过度生长的抗菌疗法
Michael Ruscio1,2, Gavin Guard1, Darla O'Dwyer3
1Integrative Medicine, Ruscio Institute for Functional Health, Austin, USA.
Cureus
|December 15, 2025
概括
在小肠细菌过度生长 (SIBO) 和肠道甲过度生长 (IMO) 的患者中,将生物膜破坏剂添加到草药抗微生物药物中显著降低了和甲水平. 需要进一步的研究来证实SIBO和IMO治疗的这些发现.
科学领域:
- 微生物学 微生物学
- 胃肠病学 胃肠病学
- 药理学 药理学是指药理学的学科.
背景情况:
- 小肠细菌过度生长 (SIBO) 和肠道甲素过度生长 (IMO) 是与各种胃肠和全身问题相关的微生物失生症状况.
- 草药抗微生物药物正在作为SIBO/IMO治疗中利法西明的非抗生素替代品进行探索.
- 与生物膜相关的耐药性可以阻碍药物和草药抗菌治疗的有效性.
研究的目的:
- 评估将生物膜破坏剂纳入SIBO/IMO草药抗菌疗法的有效性.
- 评估对根除率和微生物气体水平 (和甲) 的影响.
主要方法:
- 通过乳糖呼吸测试诊断出SIBO/IMO的13名患者的回顾性图表审查.
- 患者在8周内随机分为两组:单独使用草药抗微生物药物 (对照剂,n=5) 或使用生物膜破坏剂的草药抗微生物药物 (治疗,n=8).
主要成果:
- 与对照组相比,治疗组的 (-30.75 ppm) 和甲 (-26.38 ppm) 水平显著降低.
- 虽然SIBO根除率在两组中都很高 (60-100%),但没有观察到统计学上显著的差异.
- 没有一个组织能够彻底消灭IMO.
结论:
- 将生物膜破坏剂与草药抗微生物药物结合起来,可以提高SIBO/IMO中气和甲气水平的降低.
- 目前的草药方案,有或没有生物膜剂,显示SIBO根除率与rifaximin相似,尽管由于样本大小而不是统计显著.
- 需要进行更大规模的前性研究来验证这些初步发现,并确定生物膜干扰剂在SIBO/IMO管理中的作用.
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