在非功能性下垂体神经内分泌瘤中,Ki-67指数,瘤大小和术后结构持久性之间的关联:单个中心的经验
Carlos E Jimenez-Canizales1,2,3, Juan S Salas-Henao1, Gabriela Ballesteros-Oviedo1
1Endocrinology, University Foundation for Health Sciences, Bogotá, COL.
Cureus
|December 15, 2025
概括
非功能性垂体神经内分泌瘤 (NF-PitNETs) 是常见的. 较大的瘤大小 (≥40毫米) 和高的Ki-67指数 (≥3%) 与这些垂体瘤的术后结构性持续性增加有关.
科学领域:
- 内分泌学 在内分泌学.
- 神经外科 神经外科
- 在瘤学瘤学.
背景情况:
- 非功能性垂体神经内分泌瘤 (NF-PitNETs) 占垂体瘤的一半以上.
- 预测NF-PitNET攻击性的预测因素,如Ki-67指数和瘤大小,需要进一步调查,因为证据不一致.
- 了解与NF-PITNET结构性持久性相关的因素对于患者管理至关重要.
研究的目的:
- 评估Ki-67增殖指数和瘤大小与NF-PitNET患者手术后结构性持续性之间的关联.
- 确定用于预测NF-PITNET结果的关键病理指标.
主要方法:
- 对2010年至2020年间被诊断患有下垂体病理的患者的医疗记录进行回顾性分析.
- 包括81名符合NF-PitNET诊断特定标准的患者.
- 使用费舍尔测试进行双变量分析,以评估Ki-67指数,瘤大小和术后结构持久性之间的关系.
主要成果:
- NF-PitNETs的患病率为58%,视野障碍和头痛是最常见的症状.
- 在Ki-67指数≥3% (p=0.028) 和瘤大小≥40mm (p=0.030) 与术后结构持续性之间发现了统计学上显著的关联.
- 这些发现突出了与瘤行为相关的特定病理标志物.
结论:
- NF-PitNETs的高患病率强调了它们的临床意义.
- 瘤大小 (≥40毫米) 和Ki-67指数 (≥3%) 是NF-PitNETs手术后结构持久性的重要预测因素.
- 这些手术前和手术后的病理变量对于评估NF-PitNETs的攻击性和预后至关重要.
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