来自转基因Trichoderma reesei菌株AR-71515菌株的食物酶细胞酶的安全评估
EFSA journal. European Food Safety Authority
|December 15, 2025
概括
这项研究评估了由转基因*Trichoderma reesei**产生的食物酶细胞酶. 该酶在食品制造中使用是安全的,过敏反应的风险很低.
科学领域:
- 食品科学 食品科学 食品科学
- 酶学 是一种酶学.
- 食品安全 食品安全
背景情况:
- 细胞酶 (EC 3.2.1.4) 是一种由转基因*Trichoderma reesei* AR-715.15产生的食品酶.
- 对遗传修饰和酶生产过程的安全性问题进行了评估.
研究的目的:
- 评估食品酶细胞酶在特定食品制造工艺中使用的安全性.
- 评估潜在的饮食暴露和毒理风险.
主要方法:
- 基因毒性测试. 基因毒性测试.
- 在老鼠中进行了90天的重复剂量口服毒性研究.
- 通过氨基酸序列同质性搜索进行过敏性评估.
主要成果:
- 估计的饮食暴露量为0.070 mg TOS/kg bw/day.
- 没有观察到 1000 毫克 TOS/kg bw/day 的不良影响水平 (NOAEL) 在大鼠中被发现.
- 风险差额 (MOE) 至少为14286.6.
- 没有发现已知过敏原的同质性,过敏反应的可能性很低.
结论:
- 食品酶细胞酶在预期的使用条件下不构成安全问题.
- 没有任何酶和DNA的残留量.
- 认为过敏反应的风险较低.
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