免疫标记物将慢性牙周炎与妊娠并发症联系起来:系统性审查
Ayesha Sadiqa1, Zahra Sakina2, Faiza Fatima Chishti3
1Ayesha Sadiqa Department of Physiology, Institute of Dentistry at CMH Lahore Medical College and Institute of Dentistry, Lahore, National University of Medical Sciences (NUMS), Rawalpindi, Punjab, Pakistan.
Pakistan journal of medical sciences
|December 15, 2025
概括
慢性牙周炎显著增加了诸如早产和低出生体重等不良妊娠结果的风险. 系统性炎症调解剂在这种关联中发挥着关键作用,突出显示了妊娠期间牙周健康的重要性.
科学领域:
- 牙周病学 牙周病学
- 产科 产科 产科 产科 产科
- 免疫学 免疫学 免疫学
背景情况:
- 慢性牙周炎是一种普遍的口腔感染.
- 妊娠不良结果 (APO) 对母亲和胎儿的健康构成重大风险.
- 人们越来越多地认识到牙周炎和APO之间的联系.
研究的目的:
- 系统地审查慢性牙周炎和APO之间的因果关系.
- 为了确定参与这种关系的特定炎症调解者.
- 了解牙周炎与怀孕并发症相关的机制.
主要方法:
- 按照PRISMA 2020指南进行系统审查.
- 专注于炎症调解者的研究选择PECO模型.
- 搜索了六个主要的英语语言研究数据库 (2000-2025年).
- 发现的定性综合与偏差风险评估.
主要成果:
- 慢性牙周炎与APOs密切相关,包括妊娠糖尿病 (GDM),早产,孕前,以及低出生体重 (LBW).
- 炎症调解剂的升高,如TNF-α,IL-1β,IL-6,IL-8,CRP,PGE2,MCP-1和MMPs都与此有关.
- 这些介质会破坏胎盘功能,影响胎儿的发育.
结论:
- 牙周炎通过直接的微生物入侵和全身炎症导致APO.
- 媒介干扰胎盘功能和胎儿发育.
- 保持牙周健康对于预防妊娠并发症至关重要,如GDM,孕前,早产和LBW.
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