评估糖尿病前期患者的代谢和心血管风险:横截面研究
Ahmed M Ahmed1, Mohammed A Alsarani2, Ahmed M Alkhattabi3
1Ahmed M Ahmed Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Taibah University, Al-Madinah, Kingdom of Saudi Arabia.
Pakistan journal of medical sciences
|December 15, 2025
概括
与健康人相比,糖尿病前期患者表现出显著的代谢变化和心血管疾病风险增加. 早期查和治疗对于管理糖尿病前期及其相关风险至关重要.
科学领域:
- 内分泌学和新陈代谢学
- 心血管医学 心血管医学
- 公共卫生 公共卫生
背景情况:
- 糖尿病前期 (pre-D) 是正常葡萄糖代谢和第二类糖尿病 (T2DM) 之间的关键过渡阶段.
- 了解糖尿病前期的代谢和心血管风险概况对于及时干预至关重要.
- 血糖干扰越来越多地被认为是心血管疾病的重要贡献者.
研究的目的:
- 将糖尿病前期患者的代谢和心血管风险与T2DM患者和健康对照进行比较.
- 为了确定糖尿病前期风险的预测因素.
- 评估与糖尿病前期血糖干扰相关的心血管风险因素.
主要方法:
- 一项涉及80名糖尿病前期患者,90名T2DM患者和100名健康对照者的横截面研究.
- 测量生物化学 (FPG,HbA1c,胰岛素,脂质概况),人体 (BMI,WC,身体组成) 和临床 (血压,吸烟) 参数.
- 包括回归和交叉测试在内的统计分析,以确定预测因素并评估心血管风险.
主要成果:
- 与对照组相比,糖尿病前期和T2DM组的BMI,体脂百分比,脂肪质量,FPG,HbA1c,胰岛素和甘油三蛋白显著更高 (p <0.01).
- 体重指数 (BMI),体脂百分比,脂肪量,FPG和胰岛素被确定为糖尿病前期风险的独立预测因素 (p <0.001).
- 患有高血压,高血糖,代谢综合征,吸烟和肥胖的糖尿病前期患者显示,心血管风险的几率比率显著增加.
结论:
- 糖尿病前期与显著的代谢变化和心血管疾病风险增加有关,这强调了早期检测和管理的必要性.
- 肥胖和胰岛素抵抗是影响糖尿病前期血糖水平的关键因素.
- 生活方式因素,如吸烟和高血压和肥胖等临床条件,在糖尿病前期患者中大大放大了心血管风险.
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