探索纤维素和FIBTEM在败血症患者中可互换的作用
Hanh-Duyen Bui-Thi1, Tuan-Anh Nguyen2, Khoa Nguyen-Dang3
1Department of Intensive Care, University Medical Center Ho Chi Minh City, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Vietnam.
Therapeutic advances in hematology
|December 15, 2025
概括
在FIBTEM中,最大凝块坚定度 (MCF) 与败血症患者的纤维素水平有很强的相关性. FIBTEM MCF可以快速检测出高纤维蛋白质血症,有助于早期临床决策.
科学领域:
- 凝血科学是一门凝血科学.
- 关键护理医学 关键护理医学
- 实验室诊断 实验室诊断 实验室诊断
背景情况:
- FIBTEM是一种旋转性血栓形成显微镜 (ROTEM) 试验,可以测量基于纤维素的血栓结度.
- 它为纤维素素量化提供了克劳斯方法的更快的替代方案.
- 早期凝血评估对于患有败血症的重症患者至关重要.
研究的目的:
- 评估FIBTEM参数与败血症患者中的纤维素水平之间的相关性.
- 评估FIBTEM参数在预测高纤维素生成血症方面的有用性.
主要方法:
- 一项涉及159名败血症患者的前性观察性研究的回顾性分析.
- 评估的国际正常化比率,激活的部分血栓形成时间,血小板计数,纤维素素和FIBTEM参数 (A5,A10,A20,MCF).
- 使用了皮尔森的相关性,线性回归,布兰德-阿尔特曼图,林的CCC和ROC分析.
主要成果:
- 纤维素水平与所有FIBTEM参数 (p < 0.01) 有着强烈的相关性.
- 在FIBTEM的最大凝块坚定度 (MCF) 中,AUC值为0.905,用于预测高纤维素生成血症.
- 在22.5毫米的切线上,MCF实现了85.5%的灵敏度和83.1%的特异性.
结论:
- FIBTEM MCF是一种实用且快速的替代性标记物,用于血症中的高纤维素原体血症.
- 它可以在传统纤维素原体结果之前协助早期临床决策.
- 需要在更大的队列中进一步验证.
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